Emergence of antibiotic resistant pathogenic bacteria poses a serious public health
challenge worldwide. However, antibiotic resistance genes are not confined to the clinic; …

The process of biofouling of marine structures and substrates, such as platforms or ship
hulls, proceeds in multiple steps. Soon after the formation of an initial conditioning film …

The soil bacterium Streptomyces peucetius produces two widely used anticancer antibiotics,
doxorubicin and daunorubicin. Present within the biosynthesis gene cluster in S. peucetius …

ATP-binding cassette (ABC) systems are found in all three domains of life and in some giant
viruses and form one of the largest protein superfamilies. Most family members are transport …

DrrC is a DNA-binding protein of Streptomyces peucetius that provides self-resistance
against daunorubicin, the antibiotic produced by the organism. DrrC was expressed in E …

Background The otrC gene of Streptomyces rimosus was previously annotated as an
oxytetracycline (OTC) resistance protein. However, the amino acid sequence analysis of …

This study provides the first direct evidence for the dual role of the metalloprotease FtsH in
membrane protein biogenesis. Using the physiological substrate DrrAB, it is shown that FtsH …

Resistance to the anticancer antibiotics, doxorubicin and daunorubicin, in the producer
organism Streptomyces peucetius is conferred by an ABC transporter made of two proteins …

A novel domain, GATE (Glycine-loop And Transducer E lement), is identified in the ABC
protein DrrA. This domain shows sequence and structural conservation among close …

The human retina-specific ATP binding cassette transporter, ABCA4, plays a significant role
in the visual cycle. Mutations in the ABCA4 gene result in a broad spectrum of severe …