Breaking the Cycle: Matrix Metalloproteinase Inhibitors as an Alternative Approach in Managing Tuberculosis Pathogenesis and Progression
Mycobacterium tuberculosis (Mtb) has long posed a significant challenge to global public
health, resulting in approximately 1.6 million deaths annually. Pulmonary tuberculosis (TB) …
health, resulting in approximately 1.6 million deaths annually. Pulmonary tuberculosis (TB) …
Recent advances in injectable nanocomposite hydrogels
Injectable nanocomposite hydrogels, known for their striking similarity to the native
extracellular matrix and their minimally invasive application method, stand out as promising …
extracellular matrix and their minimally invasive application method, stand out as promising …
Trans-nasal brain delivery of anti-TB drugs by methyl-β-cyclodextrin microparticles show efficient mycobacterial clearance from central nervous system
Central nervous system tuberculosis (CNS-TB) is the most severe extra-pulmonary
manifestation of tuberculosis (TB), facing significant challenges due to the limited …
manifestation of tuberculosis (TB), facing significant challenges due to the limited …
Effective cerebral tuberculosis treatment via nose-to-brain transport of anti-TB drugs using mucoadhesive nano-aggregates
Central nervous system tuberculosis (CNS-TB) is a severe form of extra-pulmonary
tuberculosis with high mortality and morbidity rates. The standard treatment regimen for CNS …
tuberculosis with high mortality and morbidity rates. The standard treatment regimen for CNS …
Engineered vildagliptin-loaded polymeric nanoparticles via microfluidic and spray drying for enhanced antidiabetic activity
Background Vildagliptin (VLG), an antidiabetic agent, presents a potential solution to this
widespread affliction. It exhibits notable attributes, such as a high solubility and a shorter …
widespread affliction. It exhibits notable attributes, such as a high solubility and a shorter …
Targeted delivery of the metastasis-specific tumour homing TMTP1 peptide to non-small-cell lung cancer (NSCLC) using inhalable hybrid nano-assemblies
Lung cancer is one of the most fatal malignancies, with the highest death rate (∼ 19%), and
the NSCLC type accounts for∼ 85% of lung cancers. In the search for new treatments …
the NSCLC type accounts for∼ 85% of lung cancers. In the search for new treatments …
Inhalable chitosan-coated nano-assemblies potentiate niclosamide for targeted abrogation of non-small-cell lung cancer through dual modulation of autophagy and …
Lung carcinoma, particularly non-small-cell lung cancer (NSCLC), accounts for a significant
portion of cancer-related deaths, with a fatality rate of approximately 19%. Niclosamide …
portion of cancer-related deaths, with a fatality rate of approximately 19%. Niclosamide …
Recent Progress in Microenvironment‐Responsive Nanodrug Delivery Systems for the Targeted Treatment of Rheumatoid Arthritis
S Liu, M Yang, H Liu, Y Hao… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that often causes
joint pain, swelling, and functional impairments. Drug therapy is the main strategy used to …
joint pain, swelling, and functional impairments. Drug therapy is the main strategy used to …
Host-Directed Therapy with Inhalable Lovastatin Microspheres for Matrix Metalloproteinase Inhibition in Tuberculosis
Tuberculosis (TB) triggers a robust immune response, which leads to significant destruction
of the lung tissue at the site of infection, aiding in the transmission of Mycobacterium …
of the lung tissue at the site of infection, aiding in the transmission of Mycobacterium …
A critical review on developments in drying technologies for enhanced stability and bioavailability of pharmaceuticals
Drying is a widely adopted unit operation that enhances the stability of pharmaceuticals.
Conventionally, freeze-drying has been chosen, as evidenced by the numerous freeze-dried …
Conventionally, freeze-drying has been chosen, as evidenced by the numerous freeze-dried …