BACKGROUND The discovery of kisspeptin as key central regulator of GnRH secretion has
led to a new level of understanding of the neuroendocrine regulation of human reproduction …

Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Recently, a subset of neurons was identified in the arcuate nucleus of the hypothalamus that
colocalize three neuropeptides, kisspeptin, neurokinin B, and dynorphin, each of which has …

Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy)
neurons in the arcuate nucleus play a key role in GnRH pulse generation, with kisspeptin …

Gonadotropin hormone-releasing hormone (GnRH) is the key regulator of the reproductive
axis. Its pulsatile secretion determines the pattern of secretion of the gonadotropins follicle …

Neurokinin B (NKB) and its cognate receptor neurokinin 3 (NK3R) play a critical role in
reproduction. NKB and NK3R are coexpressed with dynorphin (Dyn) and kisspeptin (Kiss1) …

Kisspeptin (Kiss1) and neurokinin B (NKB)(encoded by the Kiss1 and Tac2 genes,
respectively) are indispensable for reproduction. In the female of many species, Kiss1 …

Gonadotropin-releasing hormone (GnRH) secretion has two modes of release in
mammalian species; the surge mode and the pulse mode. The surge mode, which is …

The neurohormonal control of reproduction involves a hierarchical network of central and
peripheral signals in the hypothalamic–pituitary–gonadal (HPG) axis. Development and …

Loss-of-function mutations in the genes encoding either neurokinin B (NKB) or its receptor,
NK3 (NK3R), result in hypogonadotropic hypogonadism, characterized by an absence of …