Time-dependent diffusion MRI in cancer: tissue modeling and applications

O Reynaud - Frontiers in Physics, 2017 - frontiersin.org
In diffusion weighted imaging (DWI), the apparent diffusion coefficient (ADC) has been
recognized as a useful and sensitive surrogate for cell density, paving the way for non …

Advanced MRI techniques to improve our understanding of experience-induced neuroplasticity

CL Tardif, CJ Gauthier, CJ Steele, PL Bazin, A Schäfer… - Neuroimage, 2016 - Elsevier
Over the last two decades, numerous human MRI studies of neuroplasticity have shown
compelling evidence for extensive and rapid experience-induced brain plasticity in vivo. To …

Noninvasive quantification of axon radii using diffusion MRI

J Veraart, D Nunes, U Rudrapatna, E Fieremans… - elife, 2020 - elifesciences.org
Axon caliber plays a crucial role in determining conduction velocity and, consequently, in the
timing and synchronization of neural activation. Noninvasive measurement of axon radii …

Time-dependent diffusion MRI helps predict molecular subtypes and treatment response to neoadjuvant chemotherapy in breast cancer

X Wang, R Ba, Y Huang, Y Cao, H Chen, H Xu, H Shen… - Radiology, 2024 - pubs.rsna.org
Background Time-dependent diffusion MRI has the potential to help characterize tumor cell
properties; however, to the knowledge of the authors, its usefulness for breast cancer …

In vivo imaging of cancer cell size and cellularity using temporal diffusion spectroscopy

X Jiang, H Li, J Xie, ET McKinley, P Zhao… - Magnetic resonance …, 2017 - Wiley Online Library
Purpose A temporal diffusion MRI spectroscopy based approach has been developed to
quantify cancer cell size and density in vivo. Methods A novel imaging microstructural …

Magnetic resonance imaging of mean cell size in human breast tumors

J Xu, X Jiang, H Li, LR Arlinghaus… - Magnetic resonance …, 2020 - Wiley Online Library
Purpose Cell size is a fundamental characteristic of all tissues, and changes in cell size in
cancer reflect tumor status and response to treatments, such as apoptosis and cell‐cycle …

Diffusion MRI with pulsed and free gradient waveforms: effects of restricted diffusion and exchange

A Chakwizira, CF Westin, J Brabec, S Lasič… - NMR in …, 2023 - Wiley Online Library
Monitoring time dependence with diffusion MRI yields observables sensitive to compartment
sizes (restricted diffusion) and membrane permeability (water exchange). However …

Pulsed and oscillating gradient MRI for assessment of cell size and extracellular space (POMACE) in mouse gliomas

O Reynaud, KV Winters, DM Hoang… - NMR in …, 2016 - Wiley Online Library
Solid tumor microstructure is related to the aggressiveness of the tumor, interstitial pressure
and drug delivery pathways, which are closely associated with treatment response …

Differentiation of high-grade and low-grade intra-axial brain tumors by time-dependent diffusion MRI

T Maekawa, M Hori, K Murata, T Feiweier… - Magnetic Resonance …, 2020 - Elsevier
Introduction Oscillating gradient spin-echo (OGSE) sequences enable acquisitions with
shorter diffusion times. There is growing interest in the effect of diffusion time on apparent …

Multiparametric MRI for characterization of the tumour microenvironment

E Hoffmann, M Masthoff, WG Kunz… - Nature Reviews …, 2024 - nature.com
Our understanding of tumour biology has evolved over the past decades and cancer is now
viewed as a complex ecosystem with interactions between various cellular and non-cellular …