In this Review, we describe the singular success of attractor neural network models in
describing how the brain maintains persistent activity states for working memory, corrects …

Two different perspectives have informed efforts to explain the link between the brain and
behaviour. One approach seeks to identify neural circuit elements that carry out specific …

We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution,
multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a …

Research in Neuroscience, as in many scientific disciplines, is undergoing a renaissance
based on deep learning. Unique to Neuroscience, deep learning models can be used not …

How the neocortex works is a mystery. In this paper we propose a novel framework for
understanding its function. Grid cells are neurons in the entorhinal cortex that represent the …

Episodic memory is defined as the ability to recall events in a spatiotemporal context.
Formation of such memories is critically dependent on the hippocampal formation and its …

The discovery of entorhinal grid cells has generated considerable interest in how and why
hexagonal firing fields might emerge in a generic manner from neural circuits, and what their …

The hippocampal formation is critically involved in learning and memory and contains a
large proportion of neurons encoding aspects of the organism's spatial surroundings. In the …

The study of Alzheimer's Disease (AD) has traditionally focused on neuropathological
mechanisms that has guided therapies that attenuate neuropathological features. A new …

Entorhinal cortical grid cells fire in a periodic pattern that tiles space, which is suggestive of a
spatial coordinate system. However, irregularities in the grid pattern as well as responses of …