The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication
M Tarsounas, P Sung - Nature Reviews Molecular Cell Biology, 2020 - nature.com
The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …
double-strand break (DSB) repair by homologous recombination and protects DNA …
Structural basis of homologous recombination
Homologous recombination (HR) is a pathway to faithfully repair DNA double-strand breaks
(DSBs). At the core of this pathway is a DNA recombinase, which, as a nucleoprotein …
(DSBs). At the core of this pathway is a DNA recombinase, which, as a nucleoprotein …
RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage
DNA damage prompts a diverse range of alterations to the chromatin landscape. The
RNF168 E3 ubiquitin ligase catalyzes the mono-ubiquitination of histone H2A at lysine (K) …
RNF168 E3 ubiquitin ligase catalyzes the mono-ubiquitination of histone H2A at lysine (K) …
UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4
L Barnsby-Greer, PD Mabbitt, MA Dery… - Nature Structural & …, 2024 - nature.com
UBR4 is a 574 kDa E3 ligase (E3) of the N-degron pathway with roles in neurodevelopment,
age-associated muscular atrophy and cancer. The catalytic module that carries out ubiquitin …
age-associated muscular atrophy and cancer. The catalytic module that carries out ubiquitin …
Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity
MYCBP2 is a ubiquitin (Ub) E3 ligase (E3) that is essential for neurodevelopment and
regulates axon maintenance. MYCBP2 transfers Ub to nonlysine substrates via a newly …
regulates axon maintenance. MYCBP2 transfers Ub to nonlysine substrates via a newly …
Crucial roles of the BRCA1-BARD1 E3 ubiquitin ligase activity in homology-directed DNA repair
The tumor-suppressor breast cancer 1 (BRCA1) in complex with BRCA1-associated really
interesting new gene (RING) domain 1 (BARD1) is a RING-type ubiquitin E3 ligase that …
interesting new gene (RING) domain 1 (BARD1) is a RING-type ubiquitin E3 ligase that …
The BRCA1/BARD1 ubiquitin ligase and its substrates
SR Witus, MD Stewart, RE Klevit - Biochemical Journal, 2021 - portlandpress.com
Mutations in breast cancer type 1 susceptibility protein (BRCA1) and its heterodimeric
binding partner BARD1 confer a high risk for the development of breast and ovarian …
binding partner BARD1 confer a high risk for the development of breast and ovarian …
USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A
Abstract BRCA1-BARD1-catalyzed ubiquitination of histone H2A is an important regulator of
the DNA damage response, priming chromatin for repair by homologous recombination …
the DNA damage response, priming chromatin for repair by homologous recombination …
[HTML][HTML] Clinical use and mechanisms of resistance for PARP inhibitors in homologous recombination-deficient cancers
Cells are continuously subjected to DNA damaging agents. DNA damages are repaired by
one of the many pathways guarding genomic integrity. When one or several DNA damage …
one of the many pathways guarding genomic integrity. When one or several DNA damage …
Who with whom: functional coordination of E2 enzymes by RING E3 ligases during poly‐ubiquitylation
C Lips, T Ritterhoff, A Weber, MK Janowska… - The EMBO …, 2020 - embopress.org
Protein modification with poly‐ubiquitin chains is a crucial process involved in a myriad of
cellular pathways. Chain synthesis requires two steps: substrate modification with ubiquitin …
cellular pathways. Chain synthesis requires two steps: substrate modification with ubiquitin …