The advantages and disadvantages of being polyploid

L Comai - Nature reviews genetics, 2005 - nature.com
Polyploids—organisms that have multiple sets of chromosomes—are common in certain
plant and animal taxa, and can be surprisingly stable. The evidence that has emerged from …

Gene balance hypothesis: connecting issues of dosage sensitivity across biological disciplines

JA Birchler, RA Veitia - … of the National Academy of Sciences, 2012 - National Acad Sciences
We summarize, in this review, the evidence that genomic balance influences gene
expression, quantitative traits, dosage compensation, aneuploid syndromes, population …

The multiple fates of gene duplications: deletion, hypofunctionalization, subfunctionalization, neofunctionalization, dosage balance constraints, and neutral variation

JA Birchler, H Yang - The Plant Cell, 2022 - academic.oup.com
Gene duplications have long been recognized as a contributor to the evolution of genes with
new functions. Multiple copies of genes can result from tandem duplication, from …

Polyploidy, the nucleotype, and novelty: the impact of genome doubling on the biology of the cell

JJ Doyle, JE Coate - International Journal of Plant Sciences, 2019 - journals.uchicago.edu
Polyploidy is a key mechanism of genome evolution and speciation, particularly in plants.
Many aspects of polyploidy have been elucidated with the tools that have become available …

Polyploidy: pitfalls and paths to a paradigm

DE Soltis, CJ Visger, DB Marchant… - American journal of …, 2016 - Wiley Online Library
Investigators have long searched for a polyploidy paradigm—rules or principles that might
be common following polyploidization (whole‐genome duplication, WGD). Here we attempt …

The evolutionary consequences of polyploidy

SP Otto - Cell, 2007 - cell.com
Polyploidization, the addition of a complete set of chromosomes to the genome, represents
one of the most dramatic mutations known to occur. Nevertheless, polyploidy is well …

Neopolyploidy in flowering plants

J Ramsey, DW Schemske - Annual review of ecology and …, 2002 - annualreviews.org
▪ Abstract Here we review the biology of early generation neopolyploids and discuss the
profound changes that accompany their formation. Newly formed auto-and allopolyploids …

Genome evolution in polyploids

JF Wendel - Plant molecular evolution, 2000 - Springer
Polyploidy is a prominent process in plants and has been significant in the evolutionary
history of vertebrates and other eukaryotes. In plants, interdisciplinary approaches …

Genetic and epigenetic mechanisms for gene expression and phenotypic variation in plant polyploids

ZJ Chen - Annu. Rev. Plant Biol., 2007 - annualreviews.org
Polyploidy, or whole-genome duplication (WGD), is an important genomic feature for all
eukaryotes, especially many plants and some animals. The common occurrence of …

Understanding mechanisms of novel gene expression in polyploids

TC Osborn, JC Pires, JA Birchler, DL Auger, ZJ Chen… - Trends in genetics, 2003 - cell.com
Polyploidy has long been recognized as a prominent force shaping the evolution of
eukaryotes, especially flowering plants. New phenotypes often arise with polyploid formation …