[HTML][HTML] Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

P Kong, ZY Cui, XF Huang, DD Zhang… - Signal transduction and …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

[HTML][HTML] Targeting inflammation in atherosclerosis—from experimental insights to the clinic

O Soehnlein, P Libby - Nature reviews Drug discovery, 2021 - nature.com
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …

[HTML][HTML] How vascular smooth muscle cell phenotype switching contributes to vascular disease

G Cao, X Xuan, J Hu, R Zhang, H Jin… - Cell Communication and …, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …

[PDF][PDF] Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the …

J Boren, MJ Chapman, RM Krauss… - European heart …, 2020 - academic.oup.com
OP-EHEA191011_online 2313..2340 Page 1 Low-density lipoproteins cause atherosclerotic
cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus …

Vascular smooth muscle cells in atherosclerosis: time for a re-assessment

MOJ Grootaert, MR Bennett - Cardiovascular research, 2021 - academic.oup.com
Vascular smooth muscle cells (VSMCs) are key participants in both early and late-stage
atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding …

Vascular smooth muscle cells in atherosclerosis

GL Basatemur, HF Jørgensen, MCH Clarke… - Nature reviews …, 2019 - nature.com
Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

M Bäck, A Yurdagul Jr, I Tabas, K Öörni… - Nature Reviews …, 2019 - nature.com
Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima in which the
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …

Six shades of vascular smooth muscle cells illuminated by KLF4 (Krüppel-Like Factor 4)

C Yap, A Mieremet, CJM de Vries, D Micha… - … , and vascular biology, 2021 - Am Heart Assoc
Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels
forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to …

Macrophages in atherosclerosis regression

TJ Barrett - Arteriosclerosis, thrombosis, and vascular biology, 2020 - Am Heart Assoc
Macrophages play a central role in the development of atherosclerotic cardiovascular
disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease …

HDL and reverse cholesterol transport: Basic mechanisms and their roles in vascular health and disease

M Ouimet, TJ Barrett, EA Fisher - Circulation research, 2019 - Am Heart Assoc
Cardiovascular disease, with atherosclerosis as the major underlying factor, remains the
leading cause of death worldwide. It is well established that cholesterol ester-enriched foam …