Zika virus pathogenesis and tissue tropism

JJ Miner, MS Diamond - Cell host & microbe, 2017 - cell.com
Although Zika virus (ZIKV) was isolated approximately 70 years ago, few experimental
studies had been published prior to 2016. The recent spread of ZIKV to countries in the …

Current advances in Zika vaccine development

Y Wang, L Ling, Z Zhang, A Marin-Lopez - Vaccines, 2022 - mdpi.com
Zika virus (ZIKV), an emerging arthropod-borne flavivirus, was first isolated in Uganda in
1947 from monkeys and first detected in humans in Nigeria in 1952; it has been associated …

Immunoinformatics design of a novel epitope-based vaccine candidate against dengue virus

AO Fadaka, NRS Sibuyi, DR Martin, M Goboza… - Scientific reports, 2021 - nature.com
Dengue poses a global health threat, which will persist without therapeutic intervention.
Immunity induced by exposure to one serotype does not confer long-term protection against …

Structures and functions of the envelope glycoprotein in flavivirus infections

X Zhang, R Jia, H Shen, M Wang, Z Yin, A Cheng - Viruses, 2017 - mdpi.com
Flaviviruses are enveloped, single-stranded RNA viruses that widely infect many animal
species. The envelope protein, a structural protein of flavivirus, plays an important role in …

Immunoinformatics-guided design of an epitope-based vaccine against severe acute respiratory syndrome coronavirus 2 spike glycoprotein

A Rakib, SA Sami, NJ Mimi, MM Chowdhury… - Computers in biology …, 2020 - Elsevier
Aims With a large number of fatalities, coronavirus disease-2019 (COVID-19) has greatly
affected human health worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS …

Immunoinformatics Approach for Epitope‐Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus

UK Adhikari, M Tayebi… - Journal of immunology …, 2018 - Wiley Online Library
Oropouche virus (OROV) is an emerging pathogen which causes Oropouche fever and
meningitis in humans. Several outbreaks of OROV in South America, especially in Brazil …

Epitope prediction by novel immunoinformatics approach: a state-of-the-art review

E Raoufi, M Hemmati, S Eftekhari, K Khaksaran… - International Journal of …, 2020 - Springer
Immunoinformatics is a science that helps to create significant immunological information
using bioinformatics softwares and applications. One of the most important applications of …

The impact of bioinformatics on vaccine design and development

RR María, CJ Arturo, JA Alicia, MG Paulina… - Vaccines, 2017 - books.google.com
Vaccines are the pharmaceutical products that offer the best cost‐benefit ratio in the pre‐-
vention or treatment of diseases. In that a vaccine is a pharmaceutical product, vaccine …

[Retracted] Machine Learning‐Based Ensemble Model for Zika Virus T‐Cell Epitope Prediction

SNH Bukhari, A Jain, E Haq, MA Khder… - Journal of …, 2021 - Wiley Online Library
Zika virus (ZIKV), the causative agent of Zika fever in humans, is an RNA virus that belongs
to the genus Flavivirus. Currently, there is no approved vaccine for clinical use to combat the …

Towards peptide vaccines against Zika virus: Immunoinformatics combined with molecular dynamics simulations to predict antigenic epitopes of Zika viral proteins

M Usman Mirza, S Rafique, A Ali, M Munir, N Ikram… - Scientific reports, 2016 - nature.com
The recent outbreak of Zika virus (ZIKV) infection in Brazil has developed to a global health
concern due to its likely association with birth defects (primary microcephaly) and …