Ketamine exerts rapid antidepressant action in depressed and treatment-resistant
depressed patients within hours. At the same time, ketamine elicits a unique form of …

Neuronal and synaptic plasticity are widely used terms in the field of psychiatry. However,
cellular neurophysiologists have identified two broad classes of plasticity. Hebbian forms of …

Homeostatic plasticity (HP) encompasses a suite of compensatory physiological processes
that counteract neuronal perturbations, enabling brain resilience. Currently, we lack a …

Destabilization of neural activity caused by failures of homeostatic regulation has been
hypothesized to drive the progression of Alzheimer's Disease (AD). However, the …

Neurotransmitter release is stabilized by homeostatic plasticity. Presynaptic homeostatic
potentiation (PHP) operates on timescales ranging from minute-to life-long adaptations and …

As synaptic vesicles fuse, they must continually be replaced with new docked, fusion-
competent vesicles to sustain neurotransmission. It has long been appreciated that vesicles …

Homeostatic plasticity allows neural circuits to maintain an average activity level while
preserving the ability to learn new associations and efficiently transmit information. This …

Presynaptic homeostatic plasticity (PHP) adaptively enhances neurotransmitter release
following diminished postsynaptic glutamate receptor (GluR) functionality to maintain …

Alzheimer's disease (AD) is increasingly seen as a disease of synapses and diverse
evidence has implicated the amyloid-β peptide (Aβ) in synapse damage. The molecular and …

Presynaptic homeostatic plasticity (PHP) adaptively regulates synaptic transmission in
health and disease. Despite identification of numerous genes that are essential for PHP, we …