Over the last 4 decades innovations in biomaterials and medical technology have had a
sustainable impact on the development of biopolymers, titanium/stainless steel and …

Although several major progresses have been introduced in the field of bone regenerative
medicine during the years, current therapies, such as bone grafts, still have many limitations …

The reconstruction of large defects (> 10 mm) in humans usually relies on bone graft
transplantation. Limiting factors include availability of graft material, comorbidity, and …

As life expectancy increases, malfunction or loss of tissue caused by injury or disease leads
to reduced quality of life in many patients at significant socioeconomic cost. Even though …

Melt processing is routinely used to fabricate medical polymeric devices/implants for clinical
reconstruction and can be incorporated into quality systems procedures for medical device …

The structure and architecture of scaffolds are crucial factors in scaffold-based tissue
engineering as they affect the functionality of the tissue engineered constructs and the …

The periosteum, a highly vascularized thin tissue, has excellent osteogenic and bone
regenerative abilities. The generation of periosteum-mimicking tissue has become a novel …

We have demonstrated in Part I of this study [see Schantz, J.-T., et al., Tissue Eng. 2003; 9
(Suppl. 1): S-113-S-126; this issue] that bone marrow-derived progenitor cells and calvarial …

In 1742, HL Duhamel published a report in which the osteogenic function of periosteum was
described. In 1932 HB Fell was the first to successfully culture periosteum; Fell concluded …

This study investigated a novel drug delivery system (DDS), consisting of polycaprolactone
(PCL) or polycaprolactone 20% tricalcium phosphate (PCL-TCP) biodegradable scaffolds …