Antimicrobial resistance is one of the leading concerns in medical care. Here we study the
mechanism of action of an antimicrobial cationic tripeptide, AMC-109, by combining high …

Polyanionic lipopolysaccharides (LPS) play an important role in regulating the permeability
of the outer membrane (OM) of Gram-negative bacteria. Impairment of the LPS-enriched OM …

Antimicrobial peptides (AMPs) and lipopeptides (LPs) represent very promising molecules to
fight resistant bacterial infections due to their broad-spectrum of activity, their first target, ie …

Cholesterol (Chol) content in most cellular membranes does not exceed 50 mol%, only in
the eye lens's fiber cell plasma membrane, its content surpasses 50 mol%. At this high …

Transmembrane peptides play important roles in many biological processes by interacting
with lipid membranes. This study investigates how the transmembrane domain of the …

Experimental evidence shows that the eye lens loses its elasticity dramatically with age. It
has also been reported that the cholesterol (Chol) content in the eye lens fiber cell plasma …

Membrane curvature remodeling induced by amphipathic helices (AHs) is essential in many
biological processes. Here we studied a model amphipathic peptide, M2AH, derived from …

A fragment of the human prion protein spanning residues 106–126 (PrP106–126)
recapitulates many essential properties of the disease-causing protein such as …

Modulations of synaptic membranes play an essential role in the physiological and
pathological functions of the presynaptic protein α-synuclein (αSyn). Here we used solution …

Given the increasing trend in bacterial antibiotic resistance, research on antimicrobial
peptides and their mechanisms of action has become of huge relevance in the last years …