Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

Adequate intake of the essential trace element and micronutrient selenium is thought to be
beneficial for maintaining human health. Selenium may modulate a broad spectrum of key …

The habitual intake of selenium (Se) varies strongly around the world, and many people are
at risk of inadequate supply and health risks from Se deficiency. Within the human organism …

Abstract Glutathione peroxidase 4 (GPx4) is an antioxidant enzyme reported as an inhibitor
of ferroptosis, a recently discovered non-apoptotic form of cell death. This pathway was …

Peroxynitrite—the product of the diffusion-controlled reaction of nitric oxide with superoxide
radical—is a short-lived oxidant species that is a potent inducer of cell death. Conditions in …

The element selenium was discovered in 1818 by the Swedish chemist Berzelius and was
named after the Greek goddess of the moon, Selene. 1 In biology, selenium was long …

The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …

Selenium (Se) is a nutritional trace mineral essential for various aspects of human health
that exerts its effects mainly through its incorporation into selenoproteins as the amino acid …

Reactive oxygen species (ROS) are derived from cellular oxygen metabolism and from
exogenous sources. An excess of ROS results in oxidative stress and may eventually cause …

Recent identification of new selenocysteine-containing proteins has revealed relationships
between the two trace elements selenium (Se) and iodine and the hormone network …