[HTML][HTML] Regulation of Bim in health and disease
The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway
under both physiological and pathophysiological conditions. Tight regulation of its …
under both physiological and pathophysiological conditions. Tight regulation of its …
TIF1 proteins in genome stability and cancer
RM McAvera, LJ Crawford - Cancers, 2020 - mdpi.com
Genomic instability is a hallmark of cancer cells which results in excessive DNA damage. To
counteract this, cells have evolved a tightly regulated DNA damage response (DDR) to …
counteract this, cells have evolved a tightly regulated DNA damage response (DDR) to …
ZNF410 uniquely activates the NuRD component CHD4 to silence fetal hemoglobin expression
Metazoan transcription factors typically regulate large numbers of genes. Here we identify
via a CRISPR-Cas9 genetic screen ZNF410, a pentadactyl DNA-binding protein that in …
via a CRISPR-Cas9 genetic screen ZNF410, a pentadactyl DNA-binding protein that in …
MYC activation and BCL2L11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs
CD Wood, H Veenstra, S Khasnis, A Gunnell… - Elife, 2016 - elifesciences.org
Lymphomagenesis in the presence of deregulated MYC requires suppression of MYC-
driven apoptosis, often through downregulation of the pro-apoptotic BCL2L11 gene (Bim) …
driven apoptosis, often through downregulation of the pro-apoptotic BCL2L11 gene (Bim) …
Delineating crosstalk mechanisms of the ubiquitin proteasome system that regulate apoptosis
I Gupta, K Singh, NK Varshney, S Khan - Frontiers in cell and …, 2018 - frontiersin.org
Regulatory functions of the ubiquitin-proteasome system (UPS) are exercised mainly by the
ubiquitin ligases and deubiquitinating enzymes. Degradation of apoptotic proteins by UPS is …
ubiquitin ligases and deubiquitinating enzymes. Degradation of apoptotic proteins by UPS is …
BH3-only protein BIM: an emerging target in chemotherapy
BH3-only proteins constitute major proportion of pro-apoptotic members of B-cell lymphoma
2 (Bcl-2) family of apoptotic regulatory proteins and participate in embryonic development …
2 (Bcl-2) family of apoptotic regulatory proteins and participate in embryonic development …
[HTML][HTML] A TFIID-SAGA perturbation that targets MYB and suppresses acute myeloid leukemia
Targeting of general coactivators is an emerging strategy to interfere with oncogenic
transcription factors (TFs). However, coactivator perturbations often lead to pleiotropic effects …
transcription factors (TFs). However, coactivator perturbations often lead to pleiotropic effects …
The roles of TIF1γ in cancer
C Yu, Z Ding, H Liang, B Zhang, X Chen - Frontiers in Oncology, 2019 - frontiersin.org
Transcriptional intermediary factor 1 γ (TIF1γ), also known as TRIM33, RFG7, PTC7, or
Ectodermin, is an E3 ubiquitin-ligase family member with a ring-box-coiled-coil region. It can …
Ectodermin, is an E3 ubiquitin-ligase family member with a ring-box-coiled-coil region. It can …
A transcription factor addiction in leukemia imposed by the MLL promoter sequence
Summary The Mixed Lineage Leukemia gene (MLL) is altered in leukemia by chromosomal
translocations to produce oncoproteins composed of the MLL N-terminus fused to the C …
translocations to produce oncoproteins composed of the MLL N-terminus fused to the C …
TRIM proteins in blood cancers
LJ Crawford, CK Johnston, AE Irvine - Journal of cell communication and …, 2018 - Springer
Post-translational modification of proteins with ubiquitin plays a central role in regulating
numerous cellular processes. E3 ligases determine the specificity of ubiquitination by …
numerous cellular processes. E3 ligases determine the specificity of ubiquitination by …