The present article highlights the rationale, potential and flexibility of tumor spheroid mono-
and cocultures for implementation into state of the art anti-cancer therapy test platforms …

Summation Many factors contribute to successful tumor targeting by antibodies. Besides
properties of the tumor tissue and general antibody pharmacology, a relationship exists …

Tumor-associated macrophages (TAM) are an important component of the tumor stroma and
exert several tumor-promoting activities. Strongly pro-angiogenic TAMs that reside in …

Learning Objectives After completing this course, the reader will be able to: Discuss the
technical advances that have led to recent rapid developments in monoclonal antibody …

Monocytes and tumor-associated macrophages are part of the myeloid family, a group of
hematopoietic derived cells. Monocytes are direct precursors of hematopoietic stem cell …

Antibodies can swiftly provide therapeutics to target disease-related molecules discovered
in genomic research. Antibody engineering techniques have been actively developed and …

The critical role of tumor microenvironment (TME) in tumor initiation and development has
been well-recognized after more than a century of studies. Numerous therapeutic …

Over the last 30 years the role of monoclonal antibodies in therapeutics has increased
enormously, revolutionizing treatment in most medical specialties, including neurology …

In the development of novel immune therapies for high-risk cancers, one goal is to find tumor
targets that are not widely shared by normal cells. One such target is the surface …

Retinal diseases, including age-related macular degeneration (AMD) and diabetic
retinopathy (DR) are the leading causes of blindness in adults over the age of 50 years in …