Stress is a central concept in biology and has now been widely used in psychological,
physiological, social, and even environmental fields. However, the concept of stress was …

Recent development of innovative tools for live imaging of actin filaments (F-actin) enabled
the detection of surprising nuclear structures responding to various stimuli, challenging …

The resistance of cancer cells to therapy is responsible for the death of most patients with
cancer. Epithelial-to-mesenchymal transition (EMT) has been associated with resistance to …

The integrity of the nuclear envelope (NE) is essential for maintaining the structural stability
of the nucleus. Rupture of the NE has been frequently observed in cancer cells, especially in …

Cells rapidly respond to replication stress actively slowing fork progression and inducing
fork reversal. How replication fork plasticity is achieved in the context of nuclear organization …

The nucleus is a dynamic environment containing chromatin, membraneless organelles,
and specialized molecular structures at the nuclear membrane. Within the spectrum of DNA …

Perturbation in the replication-stress response (RSR) and DNA-damage response (DDR)
causes genomic instability. Genomic instability occurs in Wiskott-Aldrich syndrome (WAS), a …

The perturbation of DNA replication, a phenomena termed “replication stress”, is a driving
force of genome instability and a hallmark of cancer cells. Among the DNA repair …

Mutations in the telomere-binding protein POT1 are associated with solid tumors and
leukemias. POT1 alterations cause rapid telomere elongation, ATR kinase activation …

Nuclear pore complexes (NPCs) have emerged as genome organizers, defining a particular
nuclear compartment enriched for SUMO protease and proteasome activities, and act as …