The dualistic role of Lyn tyrosine kinase in immune cell signaling: implications for systemic lupus erythematosus
E L'Estrange-Stranieri, TA Gottschalk… - Frontiers in …, 2024 - frontiersin.org
Systemic lupus erythematosus (SLE, lupus) is a debilitating, multisystem autoimmune
disease that can affect any organ in the body. The disease is characterized by circulating …
disease that can affect any organ in the body. The disease is characterized by circulating …
Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors
DM Rasmussen, MM Semonis, JT Greene, JM Muretta… - Elife, 2024 - elifesciences.org
The type II class of RAF inhibitors currently in clinical trials paradoxically activate BRAF at
subsaturating concentrations. Activation is mediated by induction of BRAF dimers, but why …
subsaturating concentrations. Activation is mediated by induction of BRAF dimers, but why …
Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model
G Tornillo, L Warrington, H Kendrick… - Disease Models & …, 2024 - journals.biologists.com
ABSTRACT LYN kinase is expressed in BRCA1 loss-of-function-dependent mouse
mammary tumours, in the cells of origin of such tumours, and in human breast cancer …
mammary tumours, in the cells of origin of such tumours, and in human breast cancer …
The SRC-family kinase LYN inhibits tumour growth and activates inflammatory signalling pathways in an in vivo BRCA1 loss-of-function-associated mammary tumour …
G Tornillo, L Warrington, H Kendrick, T Hay, S Beck… - bioRxiv, 2023 - biorxiv.org
We have previously demonstrated that the SRC-family kinase LYN is expressed in
mammary tumours from a BRCA1 loss-of-function-dependent mouse mammary tumour …
mammary tumours from a BRCA1 loss-of-function-dependent mouse mammary tumour …