Microbial exopolysaccharides: main examples of synthesis, excretion, genetics and extraction

F Donot, A Fontana, JC Baccou… - Carbohydrate Polymers, 2012 - Elsevier
Exopolysaccharides (EPSs) produced by microorganisms represent an industrially
untapped market. Some microorganisms can produce and excrete over 40gL− 1 of EPS in …

Microbial production of hyaluronic acid: current state, challenges, and perspectives

L Liu, Y Liu, J Li, G Du, J Chen - Microbial cell factories, 2011 - Springer
Hyaluronic acid (HA) is a natural and linear polymer composed of repeating disaccharide
units of β-1, 3-N-acetyl glucosamine and β-1, 4-glucuronic acid with a molecular weight up …

Biotechnological production of hyaluronic acid: a mini review

JH Sze, JC Brownlie, CA Love - 3 Biotech, 2016 - Springer
Hyaluronic acid (HA) is a polysaccharide found in the extracellular matrix of vertebrate
epithelial, neural and connective tissues. Due to the high moisture retention, biocompatibility …

Comprehensive review on biotechnological production of hyaluronic acid: status, innovation, market and applications

R Ucm, M Aem, Z Lhb, V Kumar, MJ Taherzadeh… - …, 2022 - Taylor & Francis
The growing, existing demand for low-cost and high-quality hyaluronic acid (HA) needs an
outlook of different possible production strategies from renewable resources with the …

Genetic basis for hyper production of hyaluronic acid in natural and engineered microorganisms

JD de Oliveira, LS Carvalho, AMV Gomes… - Microbial cell …, 2016 - Springer
Hyaluronic acid, or HA, is a rigid and linear biopolymer belonging to the class of the
glycosaminoglycans, and composed of repeating units of the monosaccharides glucuronic …

Production of specific-molecular-weight hyaluronan by metabolically engineered Bacillus subtilis 168

P Jin, Z Kang, P Yuan, G Du, J Chen - Metabolic engineering, 2016 - Elsevier
Low-molecular-weight hyaluronan (LMW-HA) has attracted much attention because of its
many potential applications. Here, we efficiently produced specific LMW-HAs from sucrose …

Efficient production of hyaluronic acid by Streptococcus zooepidemicus using two-stage semi-continuous fermentation

Y Zhang, J Dong, G Xu, R Han, J Zhou, Y Ni - Bioresource Technology, 2023 - Elsevier
Hyaluronic acid is a kind of mucopolysaccharide that has wide applications in cosmetics,
health food, and orthopedics. Using Streptococcus zooepidemicus ATCC 39920 as parent, a …

Metabolic engineering to enhance heterologous production of hyaluronic acid in Bacillus subtilis

AW Westbrook, X Ren, J Oh, M Moo-Young… - Metabolic …, 2018 - Elsevier
Hyaluronic acid (HA) is a high-value biopolymer that is produced in large scales using
attenuated strains ofgroup C streptococci. However, due to the pathogenicity and fastidious …

Versatile strategies for bioproduction of hyaluronic acid driven by synthetic biology

ZY Yao, J Qin, JS Gong, YH Ye, JY Qian, H Li… - Carbohydrate …, 2021 - Elsevier
Owing to its outstanding water-retention ability, viscoelasticity, biocompatibility and non-
immunogenicity, Hyaluronic acid (HA), a natural linear polymer alternating linked by d …

Efficient biosynthesis of polysaccharides chondroitin and heparosan by metabolically engineered Bacillus subtilis

P Jin, L Zhang, P Yuan, Z Kang, G Du, J Chen - Carbohydrate polymers, 2016 - Elsevier
Chondroitin and heparosan, important polysaccharides and key precursors of chondroitin
sulfate and heparin/heparan sulfate, have drawn much attention due to their wide …