Inositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds
and fungi to mammals. Distinct classes of kinases generate different forms of energetic …

Inositol pyrophosphates are water soluble derivatives of inositol that contain pyrophosphate
or diphosphate moieties in addition to monophosphates. The best characterised inositol …

Inositol pyrophosphates (such as IP7 and IP8) are multifunctional signaling molecules that
regulate diverse cellular activities. Inositol pyrophosphates have'high-energy' …

Inositol pyrophosphates, also designated inositol diphosphates, possess high-energy β-
phosphates that can pyrophosphorylate proteins and regulate various cellular processes …

Abstract d-myo-inositol 1, 4, 5-trisphosphate (InsP3) is a fundamental second messenger in
cellular Ca2+ mobilization. InsP3 3-kinase, a highly specific enzyme binding InsP3 in just …

Phosphatidylinositol 4, 5-bisphosphate (PIP2) is best known as a plasma membrane–bound
regulatory lipid. Although PIP2 and phosphoinositide-modifying enzymes coexist in the …

Inositol hexakisphosphate kinases (IP6Ks) phosphorylate inositol hexakisphosphate (InsP
6) to yield 5-diphosphoinositol pentakisphosphate (5-[PP]-InsP 5 or InsP 7). In this study, we …

Messenger RNA (mRNA) export from the nucleus is essential for eukaryotic gene
expression. Here we identify a transcript-selective nuclear export mechanism affecting …

Background Detecting similar ligand-binding sites in globally unrelated proteins has a wide
range of applications in modern drug discovery, including drug repurposing, the prediction …

Highly phosphorylated, soluble inositides are an emerging family of potential eukaryotic
second messengers. The mechanisms for generating an outstanding diversity of mono-and …