Onto better TRAILs for cancer treatment

D de Miguel, J Lemke, A Anel, H Walczak… - Cell Death & …, 2016 - nature.com
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as Apo-
2 ligand (Apo2L), is a member of the TNF cytokine superfamily. By cross-linking TRAIL …

TRAIL on trial: preclinical advances in cancer therapy

DW Stuckey, K Shah - Trends in molecular medicine, 2013 - cell.com
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand, or TRAIL, is a promising
anticancer agent as it can induce apoptosis in a wide range of cancers whilst generally …

Trailing TRAIL resistance: novel targets for TRAIL sensitization in cancer cells

R Trivedi, DP Mishra - Frontiers in oncology, 2015 - frontiersin.org
Resistance to chemotherapeutic drugs is the major hindrance in the successful cancer
therapy. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of …

TRAIL receptor signalling and modulation: Are we on the right TRAIL?

D Mahalingam, E Szegezdi, M Keane, S de Jong… - Cancer treatment …, 2009 - Elsevier
Tumour necrosis factor-related apoptosis-inducing ligand or Apo2 ligand (TRAIL/Apo2L) is a
member of the tumour necrosis factor (TNF) superfamily of cytokines that induces apoptosis …

TRAIL in the treatment of cancer: from soluble cytokine to nanosystems

H Alizadeh Zeinabad, E Szegezdi - Cancers, 2022 - mdpi.com
Simple Summary TRAIL is a death ligand cytokine, predominantly used by effector immune
cells to kill malignantly transformed cells. Since its discovery, TRAIL has attracted a lot of …

TNF-related apoptosis-inducing ligand (TRAIL): a new path to anti-cancer therapies

PA Holoch, TS Griffith - European journal of pharmacology, 2009 - Elsevier
Since its discovery in 1995, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL),
a member of the tumor necrosis factor super family, has been under intense focus because …

Antibody fragments as potential biopharmaceuticals for cancer therapy: success and limitations

RV Kholodenko, DV Kalinovsky… - Current Medicinal …, 2019 - ingentaconnect.com
Monoclonal antibodies (mAbs) are an important class of therapeutic agents approved for the
therapy of many types of malignancies. However, in certain cases applications of …

Targeting of the tumor necrosis factor receptor superfamily for cancer immunotherapy

E Bremer - International Scholarly Research Notices, 2013 - Wiley Online Library
The tumor necrosis factor (TNF) ligand and cognate TNF receptor superfamilies constitute
an important regulatory axis that is pivotal for immune homeostasis and correct execution of …

Is TRAIL the holy grail of cancer therapy?

T Newsom-Davis, S Prieske, H Walczak - Apoptosis, 2009 - Springer
Inducing apoptosis has become an important approach in the development of new anti-
cancer treatments. Tumour necrosis factor apoptosis inducing ligand (TRAIL) based …

Antibody–cytokine fusion proteins

RE Kontermann - Archives of biochemistry and biophysics, 2012 - Elsevier
Cytokines are key players in stimulating and regulating immune responses in physiological
and pathophysiological processes. Various cytokines have been approved for therapy of …