Since the first identification of CTNNB1 mutations in adamantinomatous craniopharyngioma
(ACP), much has been learned about the molecular pathways and processes that are …

微球剂(microspheres) 是指活性成分溶解或均匀分散在辅料(包括载体) 中形成的微小球状实体(
粒径一般在1~ 250 μm 之间). 天然高分子明胶因具有无毒无害, 来源丰富, 生物可降解等特点已 …

The aim of this study was the development of imatinib-loaded poly (d, l-lactide-co-
glycolide)(PLGA) microspheres with high loading efficiency which can afford continuous …

Imatinib is a chemotherapeutic agent known to cause severe side effects when
administrated systemically. Encapsulating imatinib in co-polymer poly (lactic-co-glycolic …

Clinical effectiveness of imatinib mesylate in cancer treatment is compromised by its off-
target cardiotoxicity. In the present study, we have developed physically stable imatinib …

Imatinib, a small molecule kinase inhibitor, is used as a cancer growth blocker. However,
one of its most serious side effects is congestive cardiac failure. Reducing drug toxicity may …

Background/Aims: Platelet-derived growth factors (PDGFs) have emerged as pivotal in
pathological angiogenesis, which is a hallmark of various tumors and retinal diseases. Here …

Purpose: The objective of this study was to investigate the therapeutic potential of poly (lactic-
co-glycolic acid)(PLGA) microspheres loaded with recombinant human growth and …

This study was premeditated to elaborate an optimized imatinib mesylate (IM)–loaded
proniosomal–derived nanovesicles to investigate its influence on IM effectiveness, cellular …

Imatinib mesylate (IM), a tyrosine kinase inhibitor, is used as targeted cancer therapy.
However, mono-targeting by IM does not always achieve full tumor eradication and thus it is …