Hepatic stellate cell (HSC), initially analyzed by von Kupffer, in 1876, revealed to be an
extraordinary mesenchymal cell, essential for both hepatocellular function and lesions …

The extracellular matrix (ECM) plays critical roles in cytoskeletal support, biomechanical
transduction and biochemical signal transformation. Tumor-associated macrophage (TAM) …

Background We and others have confirmed activation of macrophages plays a critical role in
liver injury and fibrogenesis during HBV infection. And we have also proved HBeAg can …

Background NAFLD and NASH are emerging as primary causes of chronic liver disease,
indicating a need for an effective treatment. Mutaflor® probiotic, a microbial treatment of …

Background The prevalence of impaired glucose tolerance and diabetes is much higher in
people with cirrhosis than that in the general population. However, there are inadequate …

Background Liver fibrosis (LF) is a common pathological process characterized by the
activation of hepatic stellate cells (HSCs) and accumulation of extracellular matrix. Severe …

Objective The present study aims to investigate the specific protective effects and underlying
mechanisms of Ganshuang granule (GSG) on dimethylnitrosamine (DMN)-induced hepatic …

Human stem cells are undifferentiated cells with the capacity for self-renewal and
differentiation into distinct cell lineages, playing important role in the development and …

Abstract Introduction: Chrysophanol (Cho) is a natural anthraquinone with biological effects
such as inducing ferroptosis and anticancer activity. The hepatitis B virus X protein (HBx) is …

Purpose: Chronic inflammation in the liver is a key trigger for liver injury and fibrosis in
various liver diseases. Given the anti-inflammatory and antioxidant effects of Saffron, this …