Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …

The exponential increase of patients with diabetes mellitus urges for novel therapeutic
strategies to reduce the socioeconomic burden of this disease. The loss or dysfunction of …

Human organogenesis remains relatively unexplored for ethical and practical reasons.
Here, we report the establishment of a single-cell transcriptome atlas of the human fetal …

An unlimited source of human pancreatic β cells is in high demand. Even with recent
advances in pancreatic differentiation from human pluripotent stem cells, major hurdles …

Organoids are miniaturized and simplified versions of an organ produced in vitro from stem
or progenitor cells. They are used as a model system consisting of multiple cell types …

Studies on diabetes have long been hampered by a lack of authentic disease models that,
ideally, should be unlimited and able to recapitulate the abnormalities involved in the …

Abstract Objective Islets of Langerhans contain heterogeneous populations of insulin-
producing β-cells. Surface markers and respective antibodies for isolation, tracking, and …

The HNF1α p291fsinsC truncation is the most common mutation associated with maturity-
onset diabetes of the young 3 (MODY3). Although shown to impair HNF1α signaling, the …

Embryonic and pluripotent stem cells hold great promise in generating β-cells for both
replacing medicine and novel therapeutic discoveries in diabetes mellitus. However, their …

Organoids have become one of the fastest progressing and applied models in biological
and medical research, and various organoids have now been developed for most of the …