Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related
(ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression …

The NLRP3 inflammasome is cytosolic multi-protein complex that induces inflammation and
pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators …

Gasdermin-D (GSDMD) in inflammasome-activated macrophages is cleaved by caspase-1
to generate N-GSDMD fragments. N-GSDMD then oligomerizes in the plasma membrane …

Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

Mammalian cells respond to stress by activating mechanisms that support cellular functions
and hence maintain microenvironmental and organismal homeostasis. Intracellular …

Mitophagy is a vital form of autophagy for selective removal of dysfunctional or redundant
mitochondria. Accumulating evidence implicates elimination of dysfunctional mitochondria …

Inflammasomes are multi-protein signaling complexes that trigger the activation of
inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome …

A cell is delimited by numerous borders that define specific organelles. The walls of some
organelles are particularly robust, such as in mitochondria or endoplasmic reticulum, but …

Over the past decade, numerous advances have been made in the role and regulation of
inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises …

Autophagy is well equipped functionally to isolate microbial pathogens in autophagosomes
and to carry out their clearance by dismemberment in the course of catabolic processes in …