The fight against cancer by microgravity: the multicellular spheroid as a metastasis model
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …
May the force be with you (or not): The immune system under microgravity
All terrestrial organisms have evolved and adapted to thrive under Earth's gravitational force.
Due to the increase of crewed space flights in recent years, it is vital to understand how the …
Due to the increase of crewed space flights in recent years, it is vital to understand how the …
3D biofabrication and space: A 'far-fetched dream'or a 'forthcoming reality'?
N Majumder, S Ghosh - Biotechnology Advances, 2023 - Elsevier
The long duration space missions across the Low Earth Orbit (LEO) often expose the
voyagers to an abrupt zero gravity influence. The severe extraterrestrial cosmic radiation …
voyagers to an abrupt zero gravity influence. The severe extraterrestrial cosmic radiation …
Inhibition of miR-10b treats metastatic breast cancer by targeting stem cell-like properties
A Halim, N Al-Qadi, E Kenyon, KN Conner… - …, 2024 - pmc.ncbi.nlm.nih.gov
Despite advances in breast cancer screening and treatment, prognosis for metastatic
disease remains dismal at 30% five-year survival. This is due, in large, to the failure of …
disease remains dismal at 30% five-year survival. This is due, in large, to the failure of …
Decellularized plant-derived vasculature-on-a-chip interacting with breast cancer spheroids to evaluate a dual-drug therapy
Y Filiz, Y Arslan, E Duran, P Saglam-Metiner… - Applied Materials …, 2024 - Elsevier
Breast cancer progression is a complex process involving the primary tumor and its
microenvironment supported by a vascular network. Multicellular spheroids closely mimic in …
microenvironment supported by a vascular network. Multicellular spheroids closely mimic in …
Simulated microgravity influences immunity-related biomarkers in lung cancer
Microgravity is a novel strategy that may serve as a complementary tool to develop future
cancer therapies. In lung cancer, the influence of microgravity on cellular processes and the …
cancer therapies. In lung cancer, the influence of microgravity on cellular processes and the …
[HTML][HTML] Three-dimensional growth of prostate cancer cells exposed to simulated microgravity
Prostate cancer metastasis has an enormous impact on the mortality of cancer patients.
Factors involved in cancer progression and metastasis are known to be key players in …
Factors involved in cancer progression and metastasis are known to be key players in …
Cancer studies under space conditions: Finding answers abroad
In this review article, we discuss the current state of knowledge in cancer research under
real and simulated microgravity conditions and point out further research directions in this …
real and simulated microgravity conditions and point out further research directions in this …
Prolonged exposure to simulated microgravity changes release of small extracellular vesicle in breast cancer cells
Breast cancer is the leading cause of cancer incidence worldwide and among the five
leading causes of cancer mortality. Despite major improvements in early detection and new …
leading causes of cancer mortality. Despite major improvements in early detection and new …
Dexamethasone selectively inhibits detachment of metastatic thyroid cancer cells during random positioning
D Melnik, JL Cortés-Sánchez, V Sandt, S Kahlert… - Cancers, 2023 - mdpi.com
Simple Summary Metastasis is the most dangerous feature of advanced cancers. In vitro
models of this process could help us to study and understand mechanisms that are not …
models of this process could help us to study and understand mechanisms that are not …