Synaptic loss is a pathological feature of all neurodegenerative diseases including
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS is a disease of …

Recent evidence has supported the hypothesis that amyotrophic lateral sclerosis (ALS) is a
multi-step disease, as the onset of symptoms occurs after sequential exposure to a defined …

The intricate spatial configurations of brain networks offer essential insights into
understanding the specific patterns of brain abnormalities and the underlying biological …

Deregulation of RNA metabolism has emerged as one of the key events leading to the
degeneration of motor neurons (MNs) in Amyotrophic Lateral Sclerosis (ALS) disease …

Gene mutations causing cytoplasmic mislocalization of the RNA-binding protein FUS lead to
severe forms of amyotrophic lateral sclerosis (ALS). Cytoplasmic accumulation of FUS is …

Human cellular models of neurodegeneration require reproducibility and longevity, which is
necessary for simulating age-dependent diseases. Such systems are particularly needed for …

Amyotrophic lateral sclerosis (ALS) is manifested as skeletal muscle denervation, loss of
motor neurons and finally severe respiratory failure. Mutations of RNA-binding protein FUS …

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease
that leads to the massive loss of motor neurons in cerebrum, brain stem and spinal cord. It …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease mainly
affecting upper and lower motoneurons. Several functionally heterogeneous genes have …

Key early features of amyotrophic lateral sclerosis (ALS) are denervation of neuromuscular
junctions and axonal degeneration. Motor neuron homeostasis relies on local translation …