CRISPR–Cas9 is the state-of-the-art programmable genome-editing tool widely used in
many areas. For safe therapeutic applications in clinical medicine, its off-target effect must …

Therapeutics based on clustered regularly interspaced short palindromic repeats (CRISPR)
have gained significant attention as a promising synthetic biology technique, but there are …

CRISPR (clustered regularly interspaced short palindromic repeats) technology has
achieved great breakthroughs in terms of convenience and sensitivity; it is becoming the …

Monitoring diseases caused by pathogens or by mutations in DNA sequences requires
accurate, rapid, and sensitive tools to detect specific nucleic acid sequences. Here, we …

CRISPR (clustered regularly interspaced short palindromic repeats) technology holds
tremendous promise for gene regulation and editing. However, precise control of CRISPR …

CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 is a unique
genome editing tool that can be easily used in a wide range of applications, including …

Purine and pyrimidine nucleotides are crucial building blocks for the survival of cells, and
there are layers of pathways to make sure a stable supply of them including de novo …

Although CRISPR-Cas9 gene therapies have proven to be a powerful tool across many
applications, improvements are necessary to increase the specificity of this technology …

Peptide nucleic acid (PNA) is prominent artificial nucleic acid mimetic and modifications at
the-position of the peptidic backbone are known to further enhance the desirable …

Peptide nucleic acids (PNA), synthetic molecules comprising a peptide-like backbone and
natural and unnatural nucleobases, have garnered significant attention for their potential …