[HTML][HTML] Hepatic ischemia and reperfusion injury: effects on the liver sinusoidal milieu

C Peralta, MB Jiménez-Castro, J Gracia-Sancho - Journal of hepatology, 2013 - Elsevier
Ischemia-reperfusion injury is an important cause of liver damage occurring during surgical
procedures including hepatic resection and liver transplantation, and represents the main …

The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair

B Vollmar, MD Menger - Physiological reviews, 2009 - journals.physiology.org
The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

Uremia

TW Meyer, TH Hostetter - New England Journal of Medicine, 2007 - Mass Medical Soc
The meaning of uremia, which refers to the illness accompanying kidney failure that is
unexplained by derangements in extracellular volume, inorganic ion concentrations, or lack …

Carbon monoxide protects the kidney through the central circadian clock and CD39

M Correa-Costa, D Gallo… - Proceedings of the …, 2018 - National Acad Sciences
Ischemia reperfusion injury (IRI) is the predominant tissue insult associated with organ
transplantation. Treatment with carbon monoxide (CO) modulates the innate immune …

Erythropoietin ameliorates renal ischemia and reperfusion injury via inhibiting tubulointerstitial inflammation

L Hu, C Yang, T Zhao, M Xu, Q Tang, B Yang… - Journal of Surgical …, 2012 - Elsevier
BACKGROUND: Tubulointerstitial inflammation is the characteristics of renal ischemia
reperfusion injury (IRI) that is inevitable in kidney transplantation. Erythropoietin (EPO) has …

[HTML][HTML] Carbon monoxide mechanism of protection against renal ischemia and reperfusion injury

AM Kwong, PPW Luke, RN Bhattacharjee - Biochemical Pharmacology, 2022 - Elsevier
Carbon monoxide is quickly moving past its historic label as a molecule once feared, to a
therapeutic drug that modulates inflammation. The development of carbon monoxide …

Erythropoietin enhances Kupffer cell number and activity in the challenged liver

D Gilboa, Y Haim-Ohana, N Deshet-Unger… - Scientific reports, 2017 - nature.com
Erythropoietin (EPO) is the main hormone driving mammalian erythropoiesis, with activity
mediated via the surface receptor, EPO-R, on erythroid progenitor cells. Recombinant …

Erythropoietin inhibits gluconeogenesis and inflammation in the liver and improves glucose intolerance in high-fat diet-fed mice

R Meng, D Zhu, Y Bi, D Yang, Y Wang - PloS one, 2013 - journals.plos.org
Erythropoietin (EPO) has multiple biological functions, including the modulation of glucose
metabolism. However, the mechanisms underlying the action of EPO are still obscure. This …

Long-term treatment with suberythropoietic Epo is vaso-and neuroprotective in experimental diabetic retinopathy

Q Wang, S Gorbey, F Pfister, S Höger… - Cellular Physiology and …, 2011 - karger.com
Abstract Background/Aims: Diabetic retinopathy is characterized by pericyte loss and
vasoregression both in the clinic and in animal models. A mild neurodegeneration with loss …

Induction of heme oxygenase-1 protects mouse liver from apoptotic ischemia/reperfusion injury

Z Ben-Ari, Y Issan, Y Katz, M Sultan, M Safran… - Apoptosis, 2013 - Springer
Abstract Ischemia/reperfusion (I/R) injury is the main cause of primary graft dysfunction of
liver allografts. Cobalt-protoporphyrin (CoPP)–dependent induction of heme oxygenase …