Interferon (IFN)-mediated antiviral responses are central to host defence against viral
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …

Virus entry, consisting of attachment to and penetration into the host target cell, is the first
step of the virus life cycle and is a critical 'do or die'event that governs virus emergence in …

Interferon (IFN) signaling induces the expression of a wide array of genes, collectively
referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication …

Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively,
they are highly effective at resisting and controlling pathogens. In this review, we begin by …

Viral infections continue to represent major challenges to public health, and an enhanced
mechanistic understanding of the processes that contribute to viral life cycles is necessary …

Flaviviruses such as dengue (DENV), yellow fever (YFV), West Nile (WNV), and Zika (ZIKV)
are human pathogens of global significance. In particular, DENV causes the most prevalent …

Many viruses trigger the type I interferon (IFN) system, leading to the transcription of
hundreds of interferon-stimulated genes (ISGs). The products of these ISGs exert numerous …

Over the past few years, several groups have identified new genes that are transcriptionally
induced downstream of type I interferon (IFN) signalling and that inhibit infection by …

The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus
can spread and the ability of a generally mild infection to induce severe morbidity and …

Animal cells use a wide variety of mechanisms to slow or prevent replication of viruses.
These mechanisms are usually mediated by antiviral proteins whose expression and …