The Flavivirus genus is made up of viruses that are either mosquito-borne, tick-borne and
other viruses transmitted by unknown vectors. Flaviviruses present a significant threat to …

Arthropod-borne flaviviruses are important human pathogens that cause a diverse range of
clinical conditions, including severe hemorrhagic syndromes, neurological complications …

Flaviviruses infect hundreds of millions of people annually, and no antiviral therapy is
available,. We performed a genome-wide CRISPR/Cas9-based screen to identify host …

Antibodies protect against homologous Dengue virus (DENV) infection but can precipitate
severe dengue by promoting heterotypic virus entry via Fcγ receptors (FcγR). We …

Dengue virus (DENV) is a mosquito-borne member of the Flavivirus genus and includes four
serotypes (DENV-1, DENV-2, DENV-3, and DENV-4), each of which is capable of causing …

Through the Advisory Committee on Dengue and other Flavivirus Vaccines, the World
Health Organization (WHO) has had a long-standing commitment to facilitate and to guide …

The antibody response to the envelope (E) glycoprotein of dengue virus (DENV) is known to
play a critical role in both protection from and enhancement of disease, especially after …

Flaviviruses are a group of small RNA viruses that cause severe disease in humans
worldwide and are the target of several vaccine development programs. A primary goal of …

Monoclonal antibodies (mAbs) have long provided powerful research tools for virologists to
understand the mechanisms of virus entry into host cells and of antiviral immunity. Even so …

Previous studies have demonstrated that monoclonal antibodies (MAbs) against an epitope
on the lateral surface of domain III (DIII) of the West Nile virus (WNV) envelope (E) strongly …