Host invasion by pathogenic amoebae: epithelial disruption by parasite proteins

A Betanzos, C Bañuelos, E Orozco - Genes, 2019 - mdpi.com
The epithelium represents the first and most extensive line of defence against pathogens,
toxins and pollutant agents in humans. In general, pathogens have developed strategies to …

Target identification and intervention strategies against amebiasis

S Nagaraja, S Ankri - Drug Resistance Updates, 2019 - Elsevier
Entamoeba histolytica is the etiological agent of amebiasis, which is an endemic parasitic
disease in developing countries and is the cause of approximately 70,000 deaths annually …

COP9 signalosome is an essential and druggable parasite target that regulates protein degradation

S Ghosh, L Farr, A Singh, LA Leaton, J Padalia… - PLoS …, 2020 - journals.plos.org
Understanding how the protozoan protein degradation pathway is regulated could uncover
new parasite biology for drug discovery. We found the COP9 signalosome (CSN) conserved …

Amebiasis

N Othman, JA Ujang, YL Ng, G Kumarasamy… - … in Tropical Diseases …, 2020 - Elsevier
Amebiasis is caused by Entamoeba histolytica that remains a global health burden mainly in
developing countries despite advancements in neglected tropical disease control programs …

Transcriptomic analysis reveals novel downstream regulatory motifs and highly transcribed virulence factor genes of Entamoeba histolytica

S Naiyer, D Kaur, J Ahamad, SS Singh, YP Singh… - BMC genomics, 2019 - Springer
Abstract Background Promoter motifs in Entamoeba histolytica were earlier analysed using
microarray data with lower dynamic range of gene expression. Additionally, previous …

Coordinated activity of amoebic formin and profilin are essential for phagocytosis

R Bharadwaj, A Bhattacharya… - Molecular …, 2021 - Wiley Online Library
For the protist parasite Entamoeba histolytica, endocytic processes, such as phagocytosis,
are essential for its survival in the human gut. The actin cytoskeleton is involved in the …

AtSIEK, an EXD1-like protein with KH domain, involves in salt stress response by interacting with FRY2/CPL1

X Zhang, Q Xie, L Xiang, Z Lei, Q Huang… - International Journal of …, 2023 - Elsevier
Abiotic stress has great impacts on plant germination, growth and development and crop
yield. Therefore, it is important to understand the molecular mechanism of plants response to …

An atypical EhGEF regulates phagocytosis in Entamoeba histolytica through EhRho1

R Bharadwaj, T Kushwaha, A Ahmad… - PLoS …, 2021 - journals.plos.org
The parasite Entamoeba histolytica is the etiological agent of amoebiasis, a major cause of
morbidity and mortality due to parasitic diseases in developing countries. Phagocytosis is an …

Novel regulatory roles of PtdIns(4,5)P2 generating enzyme EhPIPKI in actin dynamics and phagocytosis of Entamoeba histolytica

S Sharma, S Agarwal, R Bharadwaj… - Cellular …, 2019 - Wiley Online Library
Motility and phagocytosis are the two important processes that are intricately linked to
survival and virulence potential of the protist parasite Entamoeba histolytica. These …

Nuclear Argonaute Piwi Gene Mutation Affects rRNA by Inducing rRNA Fragment Accumulation, Antisense Expression, and Defective Processing in Drosophila …

AD Stolyarenko - International Journal of Molecular Sciences, 2020 - mdpi.com
Drosophila key nuclear piRNA silencing pathway protein Piwi of the Argonaute family has
been classically studied as a factor controlling transposable elements and fertility. Piwi has …