Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …

Melanoma, the cancer of the melanocyte, is the deadliest form of skin cancer with an
aggressive nature, propensity to metastasize and tendency to resist therapeutic intervention …

Neural crest cells are highly multipotent stem cells, but it remains unclear how their fate
restriction to specific fates occurs. The direct fate restriction model hypothesises that …

In developing melanocytes and in melanoma cells, multiple paralogs of the Activating-
enhancer-binding Protein 2 family of transcription factors (TFAP2) contribute to expression of …

Melanocyte stem cells (McSCs) of the hair follicle are necessary for hair pigmentation and
can serve as melanoma cells of origin when harboring cancer‐driving mutations. McSCs …

Melanoma heterogeneity and plasticity underlie therapy resistance. Some tumour cells
possess innate resistance, while others reprogramme during drug exposure and survive to …

Transparent immunodeficient animal models not only enhance in vivo imaging
investigations of visceral organ development but also facilitate in vivo tracking of …

Tfap2b, a pivotal transcription factor, plays critical roles within neural crest cells and their
derived lineage. To unravel the intricate lineage dynamics and contribution of these Tfap2b+ …

Melanocyte stem cells (MSCs), melanocyte lineage‐specific skin stem cells derived from the
neural crest, are observed in the mammalian hair follicle, the epidermis or the sweat gland …

Cutaneous melanoma is the most dangerous and deadly form of human skin malignancy.
Despite its rarity, it accounts for a staggering 80% of deaths attributed to cutaneous cancers …