The counterions neutralizing the charges on polyelectrolytes such as DNA or heparin may
dissociate in water and greatly influence the interaction of such polyelectrolytes with …

Isothermal titration calorimetry (ITC) is a biophysical technique for measuring the formation
and dissociation of molecular complexes and has become an invaluable tool in many …

Several virtual screening models are proposed to screen small molecules only targeting
primary miRNAs without selectivity. Few attempts have been made to develop virtual …

RNA recognition frequently results in conformational changes that optimize intermolecular
binding. As a consequence, the overall binding affinity of RNA to its binding partners …

Long noncoding RNAs (lncRNAs), defined as nontranslated transcripts greater than 200
nucleotides in length, are often differentially expressed throughout developmental stages …

The thermodynamic landscape of the CRISPR/Cas9 system plays a crucial role in
understanding and optimizing the performance of this revolutionary genome-editing …

A series of neomycin dimers have been synthesized using “click chemistry” with varying
functionality and length in the linker region to target the human immunodeficiency virus type …

Nuclear export complexes composed of rev response element (RRE) ribonucleic acid (RNA)
and multiple molecules of rev protein are promising targets for the development of …

An oligopyridylamide‐based foldamer approach has been employed to target HIV TAR RNA‐
TAT assembly as a model system to study RNA‐protein interactions. The oligopyridylamide …

Ionic self-complementary peptides are considered an important class of self-assembling
peptides. In particular, RADARADARADARADA (RADA4) is well-known to form a relatively …