Optimizing kidney preservation is a primary issue in transplantation, particularly in relation to
new donor sources, such as expanded criteria donors (ECDs) and donation after cardiac …

Chronic renal disease or acute renal injury could result in end-stage renal disease or renal
failure. Sonoporation, induced by ultrasound-targeted microbubble destruction (UTMD), has …

Most studies in gene therapy are focused on developing more efficient non-viral vectors,
ignoring their stability, even though physically and chemically stable vectors are necessary …

Non-viral vectors have attracted great interest, as they are simple to prepare, easy to modify
and relatively safe, compared to viral vectors. Kidney-targeted gene delivery systems depict …

Non-viral vectors are of interest as therapeutic gene delivery agents in gene therapy,
because they are simple to prepare, easy to modify and have definable safety profiles …

Hyperhomocysteinemia (hHcys) enhances ceramide production, leading to the activation of
NADPH oxidase and consequent glomerular oxidative stress and sclerosis. The present …

CD38 is a multifunctional protein involving in a number of signalling pathways. Given that
the lack of CD38 is considered as a dedifferentiation marker of lymphocytes and other cells …

We currently reported that Vav2, a member of the guanine nucleotide exchange factor-Vav
subfamily, participates in homocysteine-induced increases in Rac1 activity and consequent …

The use of cold preservation as a therapeutic window to deliver pharmacological or gene
therapy treatments can significantly improve both short-term and long-term graft outcomes …

Acid sphingomyelinase (ASM) has been implicated in the development of
hyperhomocysteinemia (hHcys)-induced glomerular oxidative stress and injury. However, it …