Nanobodies: robust miniprotein binders in biomedicine

JYJ Kim, Z Sang, Y Xiang, Z Shen, Y Shi - Advanced Drug Delivery …, 2023 - Elsevier
Variable domains of heavy chain-only antibodies (VHH), also known as nanobodies (Nbs),
are monomeric antigen-binding domains derived from the camelid heavy chain-only …

Research progress and applications of nanobody in human infectious diseases

Y Mei, Y Chen, JP Sivaccumar, Z An, N Xia… - Frontiers in …, 2022 - frontiersin.org
Infectious diseases, caused by pathogenic microorganisms, are capable of affecting crises.
In addition to persistent infectious diseases such as malaria and dengue fever, the vicious …

Viral G Protein–Coupled Receptors Encoded by β-and γ-Herpesviruses

MM Rosenkilde, N Tsutsumi, JM Knerr… - Annual review of …, 2022 - annualreviews.org
Herpesviruses are ancient large DNA viruses that have exploited gene capture as part of
their strategy to escape immune surveillance, promote virus spreading, or reprogram host …

HCMV antivirals and strategies to target the latent reservoir

MR Perera, MR Wills, JH Sinclair - Viruses, 2021 - mdpi.com
Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. In healthy people,
primary infection is generally asymptomatic, and the virus can go on to establish lifelong …

The complex biology of human cytomegalovirus latency

F Goodrum - Advances in virus research, 2022 - Elsevier
While many viral infections are limited and eventually resolved by the host immune
response or by death of the host, other viruses establish long-term relationships with the …

Delivery of US28 by incoming HCMV particles rapidly attenuates Akt activity to suppress HCMV lytic replication in monocytes

J Mahmud, BW Geiler, J Biswas, MJ Miller, JE Myers… - Science …, 2024 - science.org
Establishing a nonproductive, quiescent infection within monocytes is essential for the
spread of human cytomegalovirus (HCMV). We investigated the mechanisms through which …

Functional and molecular dissection of HCMV long non-coding RNAs

S Lee, H Kim, A Hong, J Song, S Lee, M Kim… - Scientific Reports, 2022 - nature.com
Small, compact genomes confer a selective advantage to viruses, yet human
cytomegalovirus (HCMV) expresses the long non-coding RNAs (lncRNAs); RNA1. 2, RNA2 …

Recent advancements in poor graft function following hematopoietic stem cell transplantation

Y Man, Z Lu, X Yao, Y Gong, T Yang… - Frontiers in …, 2022 - frontiersin.org
Poor graft function (PGF) is a life-threatening complication that occurs after transplantation
and has a poor prognosis. With the rapid development of haploidentical hematopoietic stem …

Metagenomic next-generation sequencing for the diagnosis of neonatal infectious diseases

L Chen, Y Zhao, J Wei, W Huang, Y Ma… - Microbiology …, 2022 - Am Soc Microbiol
Infectious diseases pose a fatal risk to neonates. Timely and accurate pathogen detection is
crucial for proper clinical diagnosis and therapeutic strategies. Limited sample volumes from …

Transcriptional signature of durable effector T cells elicited by a replication defective HCMV vaccine

X Ye, DJH Shih, Z Ku, J Hong, DF Barrett, RE Rupp… - npj Vaccines, 2024 - nature.com
Human cytomegalovirus (HCMV) is a leading infectious cause of birth defects and the most
common opportunistic infection that causes life-threatening diseases post-transplantation; …