Disrupted protein folding or decreased protein stability can lead to the accumulation of
(partially) un‐or misfolded proteins, which ultimately cause the formation of protein …

Conspectus Metal ions have been identified as key factors modulating the aggregation of
amyloid-β peptide (Aβ) implicated in Alzheimer's disease (AD). The presence of elevated …

Metal ions, such as copper and zinc ions, have been shown to strongly modulate the self-
assembly of the amyloid-β (Aβ) peptide into insoluble fibrils, and elevated concentrations of …

It is now well established that the blood-clotting protein fibrinogen can polymerise into an
anomalous form of fibrin that is amyloid in character; the resultant clots and microclots entrap …

The pathophysiology of ALS involves many signs of a disruption in copper homeostasis, with
both excess free levels and functional deficiency likely occurring simultaneously. This is …

Tau protein fibrillization is implicated in the pathogenesis of several neurodegenerative
diseases collectively known as Tauopathies. For decades, investigating Tau fibrillization in …

Inhibition of fibril formation is considered a possible treatment strategy for amyloid-related
diseases. Understanding the molecular nature of inhibitor action is crucial for the design of …

The discovery of effective therapeutics targeting amyloid-β (Aβ) aggregates for Alzheimer's
disease (AD) has been very challenging, which suggests its complicated etiology associated …

Microbes have been suspected to cause Alzheimer's disease since at least 1908, but this
has generally remained unpopular in comparison to the amyloid hypothesis and the …

Heavy metal ions, the common contaminants in grain growing environment and food
processing, pose an important effect on the aggregation behavior of food proteins. In this …