Mitochondria are highly plastic and dynamic organelles that have graded responses to the
changing cellular, environmental, and developmental cues. Mitochondria undergo constant …

Simple Summary The deregulation of the oxidative metabolism in cancer cells,
characterized by an increased ratio between glycolysis and oxygen consumption (Warburgv …

Omnivorous animals, including mice and humans, tend to prefer energy-dense nutrients rich
in fat over plant-based diets, especially for short periods of time, but the health …

Mitochondria are bioenergetic, biosynthetic, and signaling organelles that are integral in
stress sensing to allow for cellular adaptation to the environment. Therefore, it is not …

Oligodendrocyte precursor cells (OPCs) account for 5% of the resident parenchymal central
nervous system glial cells. OPCs are not only a back-up for the loss of oligodendrocytes that …

Abstract The PI3K/AKT/mTOR pathway is frequently activated in various human cancers and
has been considered a promising therapeutic target. Many of the positive regulators of the …

Acute kidney injury (AKI) has been widely recognized as an important risk factor for the
occurrence and development of chronic kidney disease (CKD). Even milder AKI has adverse …

The mechanistic/mammalian target of rapamycin (mTOR) plays a master role in cell
proliferation and growth in response to insulin, amino acids, energy levels, and oxygen …

Although immunotherapy by PD-1 blockade has dramatically improved the survival rate of
cancer patients, further improvement in efficacy is required to reduce the fraction of less …

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that controls a
wide spectrum of cellular processes, including cell growth, differentiation, and metabolism …