The rapid emergence since the mid-2000s of a large and diverse range of substances
originally designed as legal alternatives to more established illicit drugs (pragmatically …

Background Synthetic cannabinoids (SC) are a heterogeneous group of compounds
developed to probe the endogenous cannabinoid system or as potential therapeutics …

Background New psychoactive substances constitute a growing and dynamic class of
abused drugs in the United States. On July 12, 2016, a synthetic cannabinoid caused mass …

Rationale Recently, products containing synthetic cannabinoids, collectively referred to as
Spice, are increasingly being used recreationally. Objectives The availability, acute …

As part of an increasing worldwide use of designer drugs, recent use of compounds
containing cathinones and synthetic cannabinoids is especially prevalent. Here, we …

Synthetic cannabinoids (SCBs), also known under the brand names of “Spice,”“K2,”“herbal
incense,”“Cloud 9,”“Mojo” and many others, are becoming a large public health concern due …

BACKGROUND: The last decade has seen the appearance of myriad novel psychoactive
substances with diverse effect profiles. Synthetic cannabinoids are among the most recently …

Cannabis use is associated with an increased risk of psychosis in vulnerable individuals.
Cannabis containing high levels of the partial cannabinoid receptor subtype 1 (CB1) agonist …

A number of N-alkyl indole or indazole-3-carbonyl analogs, with modified chemical
structures, are distributed throughout the world as synthetic cannabinoids. Like synthetic …

Consumption of synthetic mind-altering compounds, also known as “new psychoactive
substances,” is increasing globally at an alarming rate. Synthetic cannabinoids (SCs) are …