[PDF][PDF] 15 years of GWAS discovery: realizing the promise

A Abdellaoui, L Yengo, KJH Verweij… - The American Journal of …, 2023 - cell.com
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …

Dissecting polygenic signals from genome-wide association studies on human behaviour

A Abdellaoui, KJH Verweij - Nature Human Behaviour, 2021 - nature.com
Genome-wide association studies on human behavioural traits are producing large amounts
of polygenic signals with significant predictive power and potentially useful biological clues …

[HTML][HTML] Gene–environment correlations across geographic regions affect genome-wide association studies

A Abdellaoui, CV Dolan, KJH Verweij, MG Nivard - Nature Genetics, 2022 - nature.com
Gene–environment correlations affect associations between genetic variants and complex
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …

Small effects: The indispensable foundation for a cumulative psychological science

FM Götz, SD Gosling… - … on psychological science, 2022 - journals.sagepub.com
We draw on genetics research to argue that complex psychological phenomena are most
likely determined by a multitude of causes and that any individual cause is likely to have …

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

R Karlsson Linnér, P Biroli, E Kong, SFW Meddens… - Nature …, 2019 - nature.com
Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …

How the science of reading informs 21st‐century education

Y Petscher, SQ Cabell, HW Catts… - Reading research …, 2020 - Wiley Online Library
The science of reading should be informed by an evolving evidence base built on the
scientific method. Decades of basic research and randomized controlled trials of …

Genetic analysis of social-class mobility in five longitudinal studies

DW Belsky, BW Domingue, R Wedow… - Proceedings of the …, 2018 - National Acad Sciences
A summary genetic measure, called a “polygenic score,” derived from a genome-wide
association study (GWAS) of education can modestly predict a person's educational and …

[HTML][HTML] Solving the missing heritability problem

AI Young - PLoS genetics, 2019 - journals.plos.org
The problem of missing heritability, that is to say the gap between heritability estimates from
genotype data and heritability estimates from twin data, has been a source of debate for …

GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background

N Sinnott-Armstrong, S Naqvi, M Rivas, JK Pritchard - Elife, 2021 - elifesciences.org
Genome-wide association studies (GWAS) have been used to study the genetic basis of a
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …

[HTML][HTML] Lottery, luck, or legacy. A review of “The Genetic Lottery: Why DNA matters for social equality”

G Coop, M Przeworski - Evolution; International Journal of Organic …, 2022 - ncbi.nlm.nih.gov
Lottery, luck, or legacy. A review of “The Genetic Lottery: Why DNA matters for social equality” -
PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …