Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions.
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …

Purpose and methods This review presents established knowledge on the effects of physical
activity (PA) on whole-body insulin sensitivity (SI) and summarises the findings of recent …

Primary aging is the progressive and inevitable process of bodily deterioration during
adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics and …

Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital
for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose …

AMPK is an evolutionary conserved sensor of cellular energy status that is activated during
exercise. Pharmacological activation of AMPK promotes glucose uptake, fatty acid oxidation …

Earlier studies have demonstrated that muscle insulin sensitivity to stimulate glucose uptake
is enhanced several hours after an acute bout of exercise. Using AICAR, we recently …

Insulin resistance is a major health risk, and although exercise clearly improves skeletal
muscle insulin sensitivity, the mechanisms are unclear. Here we show that initiation of a …

This review focuses on two paralogue Rab GTPase activating proteins known as TBC1D1
Tre-2/BUB2/cdc 1 domain family (TBC1D) 1 and TBC1D4 (also called Akt Substrate of 160 …

Enhanced skeletal muscle and whole body insulin sensitivity can persist for up to 24–48 h
after one exercise session. This review focuses on potential mechanisms for greater …

The energy/fuel sensor 5′-AMP-activated protein kinase (AMPK) is viewed as a master
regulator of cellular energy balance due to its many roles in glucose, lipid, and protein …