With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …

Neurodegenerative disorders, such as Alzheimer's disease, are often characterised by the
degeneration of the cholinergic system. Thus, the aim of many treatment regimens is to …

Abstract Comparison of ligand poses generated by protein–ligand docking programs has
often been carried out with the assumption of direct atomic correspondence between ligand …

Biomolecular recognition between ligand and protein plays an essential role in drug
discovery and development. However, it is extremely time and resource consuming to …

Nanozymes are one of the ideal alternatives to natural enzymes for various applications.
The rational design of nanozymes with improved catalytic activity stimulates increasing …

Biomimetic enzymes have emerged as ideal alternatives to natural enzymes, and there is
considerable interest in designing biomimetic enzymes with enhanced catalytic performance …

The objective of this study was to provide an updated meta-analysis of the efficacy and
safety of huperzine A (HupA) in Alzheimer's disease (AD). We searched for randomized …

The overall aim of this review is to discuss cellular mechanisms at work in the progression of
AD and current therapeutic strategies for treating AD, with a focus on the potential efficacy of …

Abstract The compound (E)-1-(2, 5-dichlorothiophen-3-yl)-3-(thiophen-2-yl)-2-propen-1-one
(DClTP) was synthesized and analyzed using FT-IR, FT-Raman and 1 H and 13 C NMR …

The high aromatic content of the deep and narrow active-site gorge of acetylcholinesterase
(AChE) is a remarkable feature of this enzyme. Here, we analyze conformational flexibility of …