Hepatocellular carcinoma (HCC) is an increasing burden on global public health and is
associated with enhanced lipogenesis, fatty acid uptake, and lipid metabolic …

Lipid metabolism reprogramming is an important hallmark of tumor progression. Cancer
cells require high levels of lipid synthesis and uptake not only to support their continued …

Background Abnormal expression of protein tyrosine phosphatases (PTPs) has been
reported to be a crucial cause of cancer. As a member of PTPs, protein tyrosine …

Cholesterol homeostasis plays a significant role in cardiovascular disease. Previous studies
have indicated that ATP-binding cassette transporter A1 (ABCA1) is one of the most …

Abstract Mammalian ferredoxin 1 and 2 (FDX1/2) belong to an evolutionary conserved
family of iron-sulfur cluster containing proteins and act as electron shutters between …

The nerve injury induced protein 2 (NINJ2) belongs to a family of homophilic adhesion
molecules and was initially found to be involved in nerve regeneration. However, the role of …

Lipid metabolism is altered in rapidly proliferating cancer cells, where fatty acids (FAs) are
utilized in the synthesis of sphingolipids and glycerophospholipids to produce cell …

Profibrotic proximal tubules (PT) were identified as a unique phenotype of proximal tubule
cells (PTCs) in renal fibrosis by single-cell RNA sequencing (scRNA-seq). Controlling the …

Ferroptosis is fairly different from other types of cell-death in biochemical processes,
morphological changes and genetics as a special programmed cell-death. Here we …

The burden of cardiovascular disease (CVD) is rising in the Asia-Pacific region, in contrast to
falling CVD mortality rates in Europe and North America. To provide new insights into the …