Molecular mechanisms of treatment resistance in glioblastoma
A Ou, WKA Yung, N Majd - International journal of molecular sciences, 2020 - mdpi.com
Glioblastoma is the most common malignant primary brain tumor in adults and is almost
invariably fatal. Despite our growing understanding of the various mechanisms underlying …
invariably fatal. Despite our growing understanding of the various mechanisms underlying …
Evolution of protein kinase signaling from yeast to man
Protein phosphorylation controls many cellular processes, especially those involved in
intercellular communication and coordination of complex functions. To explore the evolution …
intercellular communication and coordination of complex functions. To explore the evolution …
The scribble cell polarity module in the regulation of cell signaling in tissue development and tumorigenesis
R Stephens, K Lim, M Portela, M Kvansakul… - Journal of molecular …, 2018 - Elsevier
The Scribble cell polarity module, comprising Scribbled (Scrib), Discs-large (Dlg) and Lethal-
2-giant larvae (Lgl), has a tumor suppressive role in mammalian epithelial cancers. The …
2-giant larvae (Lgl), has a tumor suppressive role in mammalian epithelial cancers. The …
Single-cell RNA transcriptome helps define the limbal/corneal epithelial stem/early transit amplifying cells and how autophagy affects this population
Purpose: Single-cell RNA-sequencing (scRNA-seq) was used to interrogate the relatively
rare stem (SC) and early transit amplifying (TA) cell populations in limbal/corneal epithelia …
rare stem (SC) and early transit amplifying (TA) cell populations in limbal/corneal epithelia …
p38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP
Activation of the p38 MAP kinase pathways is crucial for the adaptation of mammalian cells
to changes in the osmolarity of the environment. Here we identify SAP97/hDlg, the …
to changes in the osmolarity of the environment. Here we identify SAP97/hDlg, the …
Computed tomography imaging in patients with congenital heart disease, part 2: technical recommendations. An expert consensus document of the Society of …
B. Kelly Han a,*, Cynthia K. Rigsby b, Jonathon Leipsic c, Dianna Bardo d, Suhny Abbara e,
Brian Ghoshhajra f, John R. Lesser g, Subha V. Raman h, Andrew M. Crean i, Edward D …
Brian Ghoshhajra f, John R. Lesser g, Subha V. Raman h, Andrew M. Crean i, Edward D …
TOPK/PBK promotes cell migration via modulation of the PI3K/PTEN/AKT pathway and is associated with poor prognosis in lung cancer
We integrated four gene expression profile data sets, namely two different pair-matched
stage I lung adenocarcinoma data sets, secondary metastatic tumors vs benign tumors and …
stage I lung adenocarcinoma data sets, secondary metastatic tumors vs benign tumors and …
PBK overexpression promotes metastasis of hepatocellular carcinoma via activating ETV4-uPAR signaling pathway
QX Yang, S Zhong, L He, XJ Jia, H Tang, ST Cheng… - Cancer letters, 2019 - Elsevier
Invasion and metastasis are the predominant causes of lethal outcomes in patients with
hepatocellular carcinoma (HCC). However, the molecular mechanism underlying the …
hepatocellular carcinoma (HCC). However, the molecular mechanism underlying the …
PDZ-binding kinase/T-LAK cell-originated protein kinase, a putative cancer/testis antigen with an oncogenic activity in breast cancer
Breast cancer is one of the most common cancers among women. To discover molecular
targets that are applicable for development of novel breast cancer therapy, we previously did …
targets that are applicable for development of novel breast cancer therapy, we previously did …
PBK/TOPK: a therapeutic target worthy of attention
Z Han, L Li, Y Huang, H Zhao, Y Luo - Cells, 2021 - mdpi.com
Accumulating evidence supports the role of PDZ-binding kinase (PBK)/T-lymphokine-
activated killer-cell-originated protein kinase (TOPK) in mitosis and cell-cycle progression of …
activated killer-cell-originated protein kinase (TOPK) in mitosis and cell-cycle progression of …