Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines

R Sartorius, M Trovato, R Manco, L D'Apice… - npj Vaccines, 2021 - nature.com
Toll-like receptors (TLRs) are transmembrane proteins belonging to the family of pattern-
recognition receptors. They function as sensors of invading pathogens through recognition …

Vaccination strategies based on bacterial self-assembling proteins as antigen delivery nanoscaffolds

F Lamontagne, V Khatri, P St-Louis, S Bourgault… - Vaccines, 2022 - mdpi.com
Vaccination has saved billions of human lives and has considerably reduced the economic
burden associated with pandemic and endemic infectious diseases. Notwithstanding major …

HIV vaccination: a roadmap among advancements and concerns

M Trovato, L D'Apice, A Prisco… - International journal of …, 2018 - mdpi.com
Since the identification of the Human Immunodeficiency Virus type 1 (HIV-1) as the etiologic
agent of AIDS (Acquired Immunodeficiency Syndrome), many efforts have been made to …

Arming filamentous bacteriophage, a nature-made nanoparticle, for new vaccine and immunotherapeutic strategies

R Sartorius, L D'Apice, A Prisco, P De Berardinis - Pharmaceutics, 2019 - mdpi.com
The pharmaceutical use of bacteriophages as safe and inexpensive therapeutic tools is
collecting renewed interest. The use of lytic phages to fight antibiotic-resistant bacterial …

PLGA microparticle formulations for tunable delivery of a nano-engineered filamentous bacteriophage-based vaccine: in vitro and in silico-supported approach

R Jamaledin, R Sartorius, C Di Natale, V Onesto… - Journal of Nanostructure …, 2024 - Springer
Bacteriophages have attracted great attention in the bioengineering field in diverse research
areas from tissue engineering to therapeutic and clinical applications. Recombinant …

Novel isoenzyme of 2‐oxoglutarate dehydrogenase is identified in brain, but not in heart

V Bunik, T Kaehne, D Degtyarev… - The FEBS …, 2008 - Wiley Online Library
2‐Oxoglutarate dehydrogenase (OGDH) is the first and rate‐limiting component of the
multienzyme OGDH complex (OGDHC) whose malfunction is associated with …

[HTML][HTML] Novel antigen delivery systems

M Trovato, P De Berardinis - World journal of virology, 2015 - ncbi.nlm.nih.gov
Vaccines represent the most relevant contribution of immunology to human health. However,
despite the remarkable success achieved in the past years, many vaccines are still missing …

Bacterial viruses against viruses pathogenic for man?

R Miedzybrodzki, W Fortuna, B Weber-Dabrowska… - Virus research, 2005 - Elsevier
In this review, we discuss possible models of bacteriophage–virus interactions. The first is
based on the mechanism by which phages may interact indirectly with viruses. Its essence is …

Vectorized delivery of alpha-galactosylceramide and tumor antigen on filamentous bacteriophage fd induces protective immunity by enhancing tumor-specific T cell …

R Sartorius, L D'Apice, P Barba, D Cipria… - Frontiers in …, 2018 - frontiersin.org
We have exploited the properties of filamentous bacteriophage fd to deliver immunologically
active lipids together with antigenic peptides. Filamentous bacteriophages resemble for size …

Humoral immune responses against gonadotropin releasing hormone elicited by immunization with phage-peptide constructs obtained via phage display

A Samoylov, A Cochran, B Schemera, M Kutzler… - Journal of …, 2015 - Elsevier
Phage display is based on genetic engineering of phage coat proteins resulting in fusion
peptides displayed on the surface of phage particles. The technology is widely used for …