Protein glycosylation and tumor microenvironment alterations driving cancer hallmarks
Decades of research have disclosed a plethora of alterations in protein glycosylation that
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …
Aberrant sialylation in cancer: therapeutic opportunities
J Munkley - Cancers, 2022 - mdpi.com
Simple Summary All cells are covered in a thick layer of sugar molecules known as glycans.
Changes to this sugar coat are common in cancer, and in particular cancer cells often …
Changes to this sugar coat are common in cancer, and in particular cancer cells often …
Metabolism, biochemical actions, and chemical synthesis of anticancer nucleosides, nucleotides, and base analogs
Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …
The distinct roles of sialyltransferases in cancer biology and onco-immunology
M Hugonnet, P Singh, Q Haas… - Frontiers in …, 2021 - frontiersin.org
Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the
enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has …
enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has …
A systematic review on the implications of O-linked glycan branching and truncating enzymes on cancer progression and metastasis
Glycosylation is the most commonly occurring post-translational modifications, and is
believed to modify over 50% of all proteins. The process of glycan modification is directed by …
believed to modify over 50% of all proteins. The process of glycan modification is directed by …
[HTML][HTML] Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion
Rationale: Bladder cancer (BC) management demands the introduction of novel molecular
targets for precision medicine. Cell surface glycoprotein CD44 has been widely studied as a …
targets for precision medicine. Cell surface glycoprotein CD44 has been widely studied as a …
Protein glycosylation in gastric and colorectal cancers: Toward cancer detection and targeted therapeutics
JA Ferreira, A Magalhaes, J Gomes, A Peixoto… - Cancer letters, 2017 - Elsevier
Glycosylation is the most frequent and structurally complex posttranslational modification in
cell-surface and secreted proteins. Glycans are major orchestrators of biological processes …
cell-surface and secreted proteins. Glycans are major orchestrators of biological processes …
[HTML][HTML] GlycoMinestruct: a new bioinformatics tool for highly accurate mapping of the human N-linked and O-linked glycoproteomes by incorporating structural …
Glycosylation plays an important role in cell-cell adhesion, ligand-binding and subcellular
recognition. Current approaches for predicting protein glycosylation are primarily based on …
recognition. Current approaches for predicting protein glycosylation are primarily based on …
[HTML][HTML] Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension
Invasive bladder tumours express the cell-surface Sialyl-Tn (STn) antigen, which stems from
a premature stop in protein O-glycosylation. The STn antigen favours invasion, immune …
a premature stop in protein O-glycosylation. The STn antigen favours invasion, immune …
Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer
Background Muscle invasive bladder cancer (MIBC) remains amongst the deadliest
genitourinary malignancies due to treatment failure and extensive molecular heterogeneity …
genitourinary malignancies due to treatment failure and extensive molecular heterogeneity …