Autophagy and the lysosomal system in cancer

S Kumar, M Sánchez-Álvarez, FN Lolo, F Trionfetti… - Cells, 2021 - mdpi.com
Autophagy and the lysosomal system, together referred to as the autophagolysosomal
system, is a cellular quality control network which maintains cellular health and homeostasis …

Canonical and noncanonical roles of fanconi anemia proteins: Implications in cancer predisposition

G Milletti, L Strocchio, D Pagliara, K Girardi, R Carta… - Cancers, 2020 - mdpi.com
Simple Summary Fanconi anemia (FA) is a genetic disorder that is characterized by bone
marrow failure (BMF), developmental abnormalities, and predisposition to cancer. In this …

The tyrosine kinase KDR is essential for the survival of HTLV-1-infected T cells by stabilizing the Tax oncoprotein

S Mohanty, S Suklabaidya, A Lavorgna, T Ueno… - Nature …, 2024 - nature.com
The tyrosine kinase KDR is essential for the survival of HTLV-1-infected T cells by stabilizing the
Tax oncoprotein | Nature Communications Skip to main content Thank you for visiting …

Do or die: HPV E5, E6 and E7 in cell death evasion

J Skelin, I Sabol, V Tomaić - Pathogens, 2022 - mdpi.com
Human papillomaviruses (HPVs) infect the dividing cells of human epithelia and hijack the
cellular replication machinery to ensure their own propagation. In the effort to adapt the cell …

Autophagy: the potential link between SARS-CoV-2 and cancer

P Habibzadeh, H Dastsooz, M Eshraghi, MJ Łos… - Cancers, 2021 - mdpi.com
Simple Summary Coronavirus disease 2019 (COVID-19) has led to a global crisis. With the
increasing number of individuals infected worldwide, the long-term consequences of this …

HPV sensitizes OPSCC cells to cisplatin-induced apoptosis by inhibiting autophagy through E7-mediated degradation of AMBRA1

M Antonioli, B Pagni, T Vescovo, R Ellis, B Cosway… - Autophagy, 2021 - Taylor & Francis
Oropharyngeal squamous cell carcinoma (OPSCC) is an increasing world health problem
with a more favorable prognosis for patients with human papillomavirus (HPV)-positive …

Oral Papillomatosis: Its Relation with Human Papilloma Virus Infection and Local Immunity—An Update

EC Andrei, IM Baniță, MC Munteanu, CJ Busuioc… - Medicina, 2022 - mdpi.com
Oral papilloma lesions may appear as a result of HPV infection, or not, and only special
molecular methods could differentiate them. Low-risk and high-risk HPV types could induce …

TRIM65 promotes cervical cancer through selectively degrading p53-mediated inhibition of autophagy and apoptosis

XY Wang, HW Mao, XH Guan, QM Huang, ZP Yu… - Frontiers in …, 2022 - frontiersin.org
Tripartite motif containing 65 (TRIM65) is an E3 ubiquitin ligase that has been implicated in a
variety of cellular processes as well as tumor progression, but its biological role and the …

Autophagy in viral development and progression of cancer

A Suares, MV Medina, O Coso - Frontiers in oncology, 2021 - frontiersin.org
Autophagy is a complex degradative process by which eukaryotic cells capture cytoplasmic
components for subsequent degradation through lysosomal hydrolases. Although this …

Autophagy in human T-cell leukemia virus type 1 (HTLV-1) induced leukemia

N Ducasa, D Grasso, P Benencio… - Frontiers in …, 2021 - frontiersin.org
Viruses play an important role in the development of certain human cancers. They are
estimated to contribute 16% to all human cancers. Human T-cell leukemia virus type 1 …