Effects of leptin on the skeleton
Leptin originates in adipocytes, including those in bone marrow, and circulates in
concentrations 20 to 90 times higher than those in the cerebrospinal fluid. It has direct …
concentrations 20 to 90 times higher than those in the cerebrospinal fluid. It has direct …
The Physiology of Obese‐Hyperglycemic Mice [ob/ob Mice]
P Lindström - The scientific world journal, 2007 - Wiley Online Library
This review summarizes key aspects of what has been learned about the physiology of
leptin deficiency as it can be observed in obese‐hyperglycemic ob/ob mice. These mice lack …
leptin deficiency as it can be observed in obese‐hyperglycemic ob/ob mice. These mice lack …
Peripheral leptin regulates bone formation
Substantial evidence does not support the prevailing view that leptin, acting through a
hypothalamic relay, decreases bone accrual by inhibiting bone formation. To clarify the …
hypothalamic relay, decreases bone accrual by inhibiting bone formation. To clarify the …
Metformin suppresses oxidative stress induced by high glucose via activation of the Nrf2/HO-1 signaling pathway in type 2 diabetic osteoporosis
B Chen, Q He, J Yang, Z Pan, J Xiao, W Chen, W Chi… - Life Sciences, 2023 - Elsevier
Background Metformin (MET) is widely used as a first-line hypoglycemic agent for the
treatment of type 2 diabetes mellitus (T2DM) and was also confirmed to have a therapeutic …
treatment of type 2 diabetes mellitus (T2DM) and was also confirmed to have a therapeutic …
A review of rodent models of type 2 diabetic skeletal fragility
RJ Fajardo, L Karim, VI Calley… - Journal of Bone and …, 2014 - academic.oup.com
Evidence indicating that adult type 2 diabetes (T2D) is associated with increased fracture
risk continues to mount. Unlike osteoporosis, diabetic fractures are associated with obesity …
risk continues to mount. Unlike osteoporosis, diabetic fractures are associated with obesity …
Fat targets for skeletal health
Emerging evidence points to a critical role for the skeleton in several homeostatic processes,
including energy balance. The connection between fuel utilization and skeletal remodeling …
including energy balance. The connection between fuel utilization and skeletal remodeling …
Skeletal phenotype of the leptin receptor–deficient db/db mouse
GA Williams, KE Callon, M Watson… - Journal of bone and …, 2011 - academic.oup.com
Leptin, a major hormonal product of the adipocyte, regulates appetite and reproductive
function through its hypothalamic receptors. The leptin receptor is present in osteoblasts and …
function through its hypothalamic receptors. The leptin receptor is present in osteoblasts and …
Effects of diabetes on bone material properties
Abstract Purpose of Review Individuals with type 1 and type 2 diabetes mellitus (T1DM,
T2DM) have an increased risk of bone fracture compared to non-diabetic controls that is not …
T2DM) have an increased risk of bone fracture compared to non-diabetic controls that is not …
[HTML][HTML] Leptin stimulates bone formation in ob/ob mice at doses having minimal impact on energy metabolism
KA Philbrick, CP Wong, AJ Branscum… - The Journal of …, 2017 - ncbi.nlm.nih.gov
Leptin, the protein product of the ob gene, is essential for normal bone growth, maturation,
and turnover. Peripheral actions of leptin occur at lower serum levels of the hormone than …
and turnover. Peripheral actions of leptin occur at lower serum levels of the hormone than …
Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice
Skeletal growth is tightly coupled to energy balance via complex and incompletely
understood mechanisms. Leptin-deficient ob/ob mice are obese and develop multiple …
understood mechanisms. Leptin-deficient ob/ob mice are obese and develop multiple …