Roles of circadian clocks in cancer pathogenesis and treatment

Y Lee - Experimental & molecular medicine, 2021 - nature.com
Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h
rhythms in cellular and bodily functions across nearly all living species. These internal clock …

Circadian rhythms, disease and chronotherapy

Y Lee, JM Field, A Sehgal - Journal of biological rhythms, 2021 - journals.sagepub.com
Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

Engineering radiosensitizer‐based metal‐phenolic networks potentiate STING pathway activation for advanced radiotherapy

J Yan, G Wang, L Xie, H Tian, J Li, B Li… - Advanced …, 2022 - Wiley Online Library
Radiotherapy, a mainstay of first‐line cancer treatment, suffers from its high‐dose radiation‐
induced systemic toxicity and radioresistance caused by the immunosuppressive tumor …

In vivo hitchhiking of immune cells by intracellular self-assembly of bacteria-mimetic nanomedicine for targeted therapy of melanoma

C Gao, Q Wang, J Li, CHT Kwong, J Wei, B Xie… - Science …, 2022 - science.org
Cell-based drug carriers are mostly prepared in vitro, which may negatively affect the
physiological functions of cells, and induce possible immune rejections when applied to …

Circadian rhythm and disease: Relationship, new insights, and future perspectives

AR Neves, T Albuquerque, T Quintela… - Journal of cellular …, 2022 - Wiley Online Library
The circadian system is responsible for internal functions and regulation of the organism
according to environmental cues (zeitgebers). Circadian rhythm dysregulation or …

Circadian regulation of cancer cell and tumor microenvironment crosstalk

W Xuan, F Khan, CD James, AB Heimberger… - Trends in cell …, 2021 - cell.com
Circadian rhythms regulate a remarkable variety of physiologic functions in living organisms.
Circadian disruption is associated with tumorigenesis and tumor progression through effects …

Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans

BSC Koritala, KI Porter, OA Arshad… - Journal of pineal …, 2021 - Wiley Online Library
Circadian disruption has been identified as a risk factor for health disorders such as obesity,
cardiovascular disease, and cancer. Although epidemiological studies suggest an increased …

Circadian rhythms in anticancer immunity: mechanisms and treatment opportunities

R Pick, C Wang, Q Zeng, ZM Gül… - Annual review of …, 2024 - annualreviews.org
Circadian rhythms of approximately 24 h have emerged as important modulators of the
immune system. These oscillations are important for mounting short-term, innate immune …

In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells

X Zhu, Y Suo, Y Fu, F Zhang, N Ding, K Pang… - Light: Science & …, 2021 - nature.com
Circulating tumor cells (CTCs) is an established biomarker of cancer metastasis. The
circulation dynamics of CTCs are important for understanding the mechanisms underlying …

[HTML][HTML] Major roles of the circadian clock in cancer

C Huang, C Zhang, Y Cao, J Li, F Bi - Cancer Biology & Medicine, 2023 - ncbi.nlm.nih.gov
Circadian rhythms are natural rhythms that widely exist in all creatures, and regulate the
processes and physiological functions of various biochemical reactions. The circadian clock …