Healthcare workers (HCWs) are at increased risk of exposure to tuberculosis (TB).
Traditionally, screening for latent TB infection (LTBI) is done using the tuberculin skin test …

Background Variability in interferon-gamma release assays (IGRAs) results for tuberculosis
has implications for interpretation of results close to the cut-point, and for defining thresholds …

In 2005, CDC published guidelines for using the QuantiFERON-TB Gold test (QFT-
G)(Cellestis Limited, Carnegie, Victoria, Australia)(CDC. Guidelines for using the …

Rationale: Although IFN-γ release assays (IGRAs) are widely used to screen for
Mycobacterium tuberculosis infection in high-income countries, published data on …

Interferon-release assays (IGRAs) represent advances in tuberculosis immunology and
evolutionary biology. IGRAs were designed to replace tuberculin skin test (TST) for the …

IGRAs may still be useful in high-burden settings in specific subgroups at high risk of
progression, including young children, HIV-infected individuals and healthcare workers, but …

Rationale: The optimal strategy for the diagnosis of latent tuberculosis infection is
controversial. Adoption of a two-step strategy (tuberculin skin test [TST] followed by an IFN-γ …

Rationale: Interferon-γ release assays are used to diagnose tuberculosis infection. In
developed countries, high rates of reversion following conversion have been described …

Rationale: Interferon gamma (IFN-γ) release assays for latent tuberculosis infection result in
a larger-than-expected number of conversions and reversions in occupational screening …

BACKGROUND: Interferon-gamma assays (IGRAs) are alternatives to the tuberculin skin
test (TST), but IGRA conversions and reversions are not well understood. In a pilot study, we …