[HTML][HTML] Targeting cancer metabolism in the era of precision oncology
One hundred years have passed since Warburg discovered alterations in cancer
metabolism, more than 70 years since Sidney Farber introduced anti-folates that …
metabolism, more than 70 years since Sidney Farber introduced anti-folates that …
CD8+ T cell metabolism in infection and cancer
M Reina-Campos, NE Scharping… - Nature Reviews …, 2021 - nature.com
Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …
malignant cells and can provide long-term protective immunity. In the response to infection …
Crosstalk between glucose metabolism, lactate production and immune response modulation
L Ye, Y Jiang, M Zhang - Cytokine & growth factor reviews, 2022 - Elsevier
Metabolites of glycolytic metabolism have been identified as signaling molecules and
regulators of gene expression, in addition to their basic function as major energy and …
regulators of gene expression, in addition to their basic function as major energy and …
[HTML][HTML] Epigenetic modulation of antitumor immunity for improved cancer immunotherapy
Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …
in the activation, differentiation and effector function (s) of immune cells. In this review, we …
[HTML][HTML] Carbon source availability drives nutrient utilization in CD8+ T cells
How environmental nutrient availability impacts T cell metabolism and function remains
poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) …
poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) …
Insights gained from single-cell analysis of immune cells in the tumor microenvironment
Understanding tumor immune microenvironments is critical for identifying immune modifiers
of cancer progression and developing cancer immunotherapies. Recent applications of …
of cancer progression and developing cancer immunotherapies. Recent applications of …
[HTML][HTML] Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies
S Koyama, H Nishikawa - Journal for immunotherapy of cancer, 2021 - ncbi.nlm.nih.gov
With the broad application of cancer immunotherapies such as immune checkpoint inhibitors
in multiple cancer types, the immunological landscape in the tumor microenvironment (TME) …
in multiple cancer types, the immunological landscape in the tumor microenvironment (TME) …
An engineered IL-2 partial agonist promotes CD8+ T cell stemness
Adoptive transfer of antigen-specific T cells represents a major advance in cancer
immunotherapy, with robust clinical outcomes in some patients. Both the number of …
immunotherapy, with robust clinical outcomes in some patients. Both the number of …
Strategies to therapeutically modulate cytokine action
WJ Leonard, JX Lin - Nature Reviews Drug Discovery, 2023 - nature.com
Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …
functions, including development, differentiation, growth and survival. Accordingly, the …
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy
Metabolic programming in the tumor microenvironment (TME) alters tumor immunity and
immunotherapeutic response in tumor-bearing mice and patients with cancer. Here, we …
immunotherapeutic response in tumor-bearing mice and patients with cancer. Here, we …